Skip to main content

Advertisement

SpringerLink
Log in

Relevance of CT and MRI in retinoblastoma for the diagnosis of postlaminar invasion with normal-size optic nerve: a retrospective study of 150 patients with histological comparison

  • Original Article
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

Background

Detection of optic nerve invasion is mandatory in children primarily enucleated for retinoblastoma to ensure a free resection margin.

Objective

To assess the accuracy of CT and MRI for the detection of postlaminar invasion in normal-size nerves.

Materials and methods

A total of 150 patients enucleated for retinoblastoma were included. Imaging data (119 CT and 46 MRI) were retrospectively reviewed and compared with histological findings. Abnormal contrast enhancement of the optic nerve was used as diagnostic criterion for invasion. The associations between postlaminar invasion and several indirect signs were also assessed. Statistical analysis was performed with the Kruskal-Wallis and Fisher exact tests.

Results

Postlaminar invasion on histology was observed in 8% (12/150). The sensitivity, specificity, accuracy and negative and positive predictive values were 60%, 95%, 91%, 95% and 60% for MRI, and 0%, 100%, 94% and 94% (PPV not assessable) for CT, respectively. Tumour diameter was the only indirect radiological sign significantly associated with postlaminar optic nerve invasion (P=0.002).

Conclusion

Our results suggest that MRI is more relevant than CT for preoperative detection of optic nerve invasion in patients with retinoblastoma. Tumour diameter is the only indirect sign significantly associated with postlaminar invasion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Doz F, Brisse H, Stoppa-Lyonnet D et al (2004) Retinoblastoma. In: Pinkerton R, Plowman P, Pieters R (eds) Paediatric oncology. Arnold, London, pp 323–338

    Google Scholar 

  2. Shields CL, Meadows AT, Leahey AM et al (2004) Continuing challenges in the management of retinoblastoma with chemotherapy. Retina 24:849–862

    Article  PubMed  Google Scholar 

  3. Shields CL, Shields JA, Baez K et al (1994) Optic nerve invasion of retinoblastoma. Metastatic potential and clinical risk factors. Cancer 73:692–698

    Article  PubMed  CAS  Google Scholar 

  4. Khelfaoui F, Validire P, Auperin A et al (1996) Histopathologic risk factors in retinoblastoma: a retrospective study of 172 patients treated in a single institution. Cancer 77:1206–1213

    Article  PubMed  CAS  Google Scholar 

  5. Magramm I, Abramson DH, Ellsworth RM (1989) Optic nerve involvement in retinoblastoma. Ophthalmology 96:217–222

    PubMed  CAS  Google Scholar 

  6. Bellaton E, Bertozzi AI, Behar C et al (2003) Neoadjuvant chemotherapy for extensive unilateral retinoblastoma. Br J Ophthalmol 87:327–329

    Article  PubMed  CAS  Google Scholar 

  7. John-Mikolajewski V, Messmer E, Sauerwein W et al (1987) Orbital computed tomography. Does it help in diagnosing the infiltration of choroid, sclera and/or optic nerve in retinoblastoma? Ophthalmic Paediatr Genet 8:101–104

    PubMed  CAS  Google Scholar 

  8. Jacquemin C, Karcioglu ZA (1998) Detection of optic nerve involvement in retinoblastoma with enhanced computed tomography. Eye 12:179–183

    PubMed  Google Scholar 

  9. Ainbinder DJ, Haik BG, Frei DF et al (1996) Gadolinium enhancement: improved MRI detection of retinoblastoma extension into the optic nerve. Neuroradiology 38:778–781

    Article  PubMed  CAS  Google Scholar 

  10. de Graaf P, Barkhof F, Moll AC et al (2005) Retinoblastoma: MR imaging parameters in detection of tumor extent. Radiology 235:197–207

    Article  PubMed  Google Scholar 

  11. Schueler AO, Hosten N, Bechrakis NE et al (2003) High resolution magnetic resonance imaging of retinoblastoma. Br J Ophthalmol 87:330–335

    Article  PubMed  CAS  Google Scholar 

  12. Lemke AJ, Kazi I, Mergner U et al (2007) Retinoblastoma – MR appearance using a surface coil in comparison with histopathological results. Eur Radiol 17:49–60

    Article  PubMed  Google Scholar 

  13. Galluzzi P, Cerase A, Hadjistilianou T et al (2003) Retinoblastoma: abnormal gadolinium enhancement of anterior segment of eyes at MR imaging with clinical and histopathologic correlation. Radiology 228:683–690

    Article  PubMed  Google Scholar 

  14. Karim S, Clark RA, Poukens V et al (2004) Demonstration of systematic variation in human intraorbital optic nerve size by quantitative magnetic resonance imaging and histology. Invest Ophthalmol Vis Sci 45:1047–1051

    Article  PubMed  Google Scholar 

  15. Shields JA, Shields CL, De Potter P (1992) Enucleation technique for children with retinoblastoma. J Pediatr Ophthalmol Strabismus 29:213–215

    PubMed  CAS  Google Scholar 

  16. Kaste SC, Jenkins JJ III, Pratt CB et al (2000) Retinoblastoma: sonographic findings with pathologic correlation in pediatric patients. AJR 175:495–501

    PubMed  CAS  Google Scholar 

  17. Finger PT, Khoobehi A, Ponce-Contreras MR et al (2002) Three dimensional ultrasound of retinoblastoma: initial experience. Br J Ophthalmol 86:1136–1138

    Article  PubMed  CAS  Google Scholar 

  18. Finger PT, Garcia JP Jr, Pro MJ et al (2005) “C-scan” ultrasound imaging of optic nerve extension of retinoblastoma. Br J Ophthalmol 89:1225–1226

    Article  PubMed  CAS  Google Scholar 

  19. Aerts I, Pacquement H, Doz F et al (2004) Outcome of second malignancies after retinoblastoma: a retrospective analysis of 25 patients treated at the Institut Curie. Eur J Cancer 40:1522–1529

    Article  PubMed  Google Scholar 

  20. Kaufman LM, Mafee MF, Song CD (1998) Retinoblastoma and simulating lesions. Role of CT, MR imaging and use of Gd-DTPA contrast enhancement. Radiol Clin North Am 36:1101–1117

    Article  PubMed  CAS  Google Scholar 

  21. Mafee MF, Goldberg MF, Greenwald MJ et al (1987) Retinoblastoma and simulating lesions: role of CT and MR imaging. Radiol Clin North Am 25:667–682

    PubMed  CAS  Google Scholar 

  22. Potter PD, Shields CL, Shields JA et al (1996) The role of magnetic resonance imaging in children with intraocular tumors and simulating lesions. Ophthalmology 103:1774–1783

    PubMed  CAS  Google Scholar 

  23. Smirniotopoulos JG, Bargallo N, Mafee MF (1994) Differential diagnosis of leukokoria: radiologic-pathologic correlation. Radiographics 14:1059–1079

    PubMed  CAS  Google Scholar 

  24. Barkhof F, Smeets M, van der Valk P et al (1997) MR imaging in retinoblastoma. Eur Radiol 7:726–731

    PubMed  CAS  Google Scholar 

  25. Gizewski ER, Wanke I, Jurklies C et al (2005) T1 Gd-enhanced compared with CISS sequences in retinoblastoma: superiority of T1 sequences in evaluation of tumour extension. Neuroradiology 47:56–61

    Article  PubMed  Google Scholar 

  26. Brisse HJ, Lumbroso L, Freneaux PC et al (2001) Sonographic, CT, and MR imaging findings in diffuse infiltrative retinoblastoma: report of two cases with histologic comparison. AJNR 22:499–504

    PubMed  CAS  Google Scholar 

  27. Breslau J, Dalley R, Tsuruda J et al (1995) Phased-array surface coil MR of the orbits and optic nerves. AJNR 16:1247–1251

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Institute Curie, 26 rue d’Ulm, Paris, 75005, France

    Hervé J. Brisse, Myriam Guesmi & Sylvia Neuenschwander

  2. Department of Paediatric Oncology, Institute Curie, Paris, France

    Isabelle Aerts & François Doz

  3. Department of Paediatrics, Faculty of Medicine, Paris V René Descartes, Paris, France

    François Doz

  4. Department of Pathology, Institute Curie, Paris, France

    Xavier Sastre-Garau

  5. Department of Biostatistics, Institute Curie, Paris, France

    Alexia Savignoni, Bernard Asselain & Danièle Bours

  6. Department of Ocular Oncology, Institute Curie, Paris, France

    Livia Lumbroso-Le Rouic & Laurence Desjardins

Authors
  1. Hervé J. Brisse
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Myriam Guesmi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Isabelle Aerts
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xavier Sastre-Garau
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alexia Savignoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Livia Lumbroso-Le Rouic
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Laurence Desjardins
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. François Doz
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Bernard Asselain
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Danièle Bours
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Sylvia Neuenschwander
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hervé J. Brisse.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brisse, H.J., Guesmi, M., Aerts, I. et al. Relevance of CT and MRI in retinoblastoma for the diagnosis of postlaminar invasion with normal-size optic nerve: a retrospective study of 150 patients with histological comparison. Pediatr Radiol 37, 649–656 (2007). https://doi.org/10.1007/s00247-007-0491-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00247-007-0491-4

Keywords

Search

Navigation