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MRI/MRA evaluation of sickle cell disease of the brain

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Abstract

Sickle cell disease is a major cause of pediatric stroke. Understanding the disease that affects the brain as infarctions, both clinically apparent and silent, requires an understanding of how the blood vessels are affected, the way in which both the brain and the blood vessels are imaged by MRI and MRA and the mechanism of injury.

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References

  1. Ohene-Frempong K, Weiner SJ, Sleeper LA, et al (1998) Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood 91:288–294

    CAS  PubMed  Google Scholar 

  2. Moser FG, Miller ST, Bello JA, et al (1996) The spectrum of brain MR abnormalities in sickle cell disease: a report from the Cooperative Study of Sickle Cell Disease. Am J Neuroradiol 17:965–972

    Google Scholar 

  3. Pegelow CH, Macklin EA, Moser FG, et al (2002) Longitudinal changes in brain magnetic resonance imaging findings in children cell disease. Blood 99:3014–3018

    Google Scholar 

  4. Stockman JA, Nigro MA, Mishkin MM, et al (1972) Occlusion of large cerebral vessels in sickle cell anemia. N Engl J Med 287:846–849

    Google Scholar 

  5. Goldberg HI, Zimmerman RA (1987) Central nervous system. Semin Roentgenol 22:205–212

    Google Scholar 

  6. Merkel KHH, Ginsberg PL, Parker JC, et al (1978) Cerebrovascular disease in sickle cell anemia: a clinical pathological and radiological correlation. Stroke 9:45–52

    Google Scholar 

  7. Kandeel AY, Zimmerman RA, Ohene-Frempong K (1996) Comparison of magnetic resonance angiography and conventional angiography in sickle cell disease: clinical significance and reliability. Neuroradiology 38:409–416

    Google Scholar 

  8. Brody AS, Sorette MP, Gooding CA, et al (1985) Induced alignment of flowing sickle erythrocytes in a magnetic field. A preliminary report. Invest Radiol 20:560–566

    Google Scholar 

  9. Tzika AA, Massoth RJ, Ball WS, et al (1993) Cerebral perfusion in children: detection with dynamic contrast-enhanced T2*-weighted MR images. Radiology 187:449–458

    Google Scholar 

  10. Kirkham FJ, Calamante F, Bynevelt M, et al (2001) Perfusion magnetic resonance abnormalities in patients with sickle cell disease. Ann Neurol 49:477–485

    Google Scholar 

  11. Grueneich R, Ris D, Ball W, et al (2004) Relationship of structural magnetic resonance imaging, magnetic resonance perfusion, and other disease factors to neuropsychological outcome in sickle cell disease. J Pediatr Psychol 29:83–92

    Google Scholar 

  12. Abboud MR, Cure J, Granger S, et al (2004) Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial Doppler ultrasonography findings enrolled in the STOP study. Blood 103:2822–2826

    Google Scholar 

  13. Zimmerman RA, Haselgrove JC, Wang Z, et al (1998) Advances in pediatric neuroimaging. Brain Dev 20:275–279

    Google Scholar 

  14. Zimmerman RA, Gill F, Goldberg HI, et al (1987) MRI of sickle cell cerebral infarction. Neuroradiology 29:232–237

    Google Scholar 

  15. Miller ST, Macklin EA, Pegelow CH, et al (2001) Silent infarction as a risk factor for overt stroke in children with sickle cell anemia: a report from the Cooperative Study of Sickle Cell Disease. J Pediatr 139:385–390

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Childrens Hospital, 34th St and Civic Ctr Blvd, Philadelphia, PA, 19104, USA

    Robert A. Zimmerman

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  1. Robert A. Zimmerman
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Correspondence to Robert A. Zimmerman.

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Zimmerman, R.A. MRI/MRA evaluation of sickle cell disease of the brain. Pediatr Radiol 35, 249–257 (2005). https://doi.org/10.1007/s00247-005-1420-z

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  • DOI: https://doi.org/10.1007/s00247-005-1420-z

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