Abstract
Bilateral cystic adrenal tumours are a rare presentation of neuroblastoma. Intratumoural haemorrhage is a frequent finding in neuroblastoma, but is rarely symptomatic. We present an 11-month-old girl with predominantly cystic bilateral neuroblastomas and distant lymph-node metastasis. Massive intracystic haemorrhage and superior vena cava (SVC) syndrome were ominous prognostic factors, leading to death. Large tumours with intracystic haemorrhage might require a conservative approach.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Lanzkowsky P (2000) Neuroblastoma. In: Lanzkowsky P (ed) Manual of pediatric hematology and oncology. Academic, San Diego, pp 493–512
Brodeur GM, Maris JM (2002) Neuroblastoma. In: Pizzo PA, Poplack DG (eds) Principles and practice of pediatric oncology. Lippincott, Williams and Wilkins, Philadelphia, pp 895–937
Kramer SA, Bradford WD, Anderson EE (1980) Bilateral adrenal neuroblastoma. Cancer 45:2208–2212
Ishiguro Y, Iio K, Seo T, et al (1994) Bilateral adrenal neuroblastoma. Eur J Pediatr Surg 4:37–39
Zaizen Y, Suita S, Yamanaka K, et al (1997) Bilateral adrenal neuroblastoma. Eur J Pediatr Surg 7:304–307
Atkinson GO Jr, Zaatari GS, Lorenzo RL, et al (1986) Cystic neuroblastoma in infants: radiographic and pathologic features. AJR 146:113–117
Croitoru DP, Sinsky AB, Laberge JM (1992) Cystic neuroblastoma. J Pediatr Surg 27:1320–1321
Richards ML, Gundersen AE, Williams MS (1995) Cystic neuroblastoma of infancy. J Pediatr Surg 30:1354–1357
Kozakewich HP, Perez-Atayde AR, Donovan MJ, et al (1998) Cystic neuroblastoma: emphasis on gene expression, morphology, and pathogenesis. Pediatr Dev Pathol 1:17–28
Cassady C, Winters WD (1997) Bilateral cystic neuroblastoma: imaging features and differential diagnoses. Pediatr Radiol 27:758–759
Lee SY, Chuang JH, Huang CB, et al (1998) Congenital bilateral cystic neuroblastoma with liver metastases and massive intracystic haemorrhage. Br J Radiol 7:1205–1207
Murthy TV, Irving IM, Lister J (1978) Massive adrenal hemorrhage in neonatal neuroblastoma. J Pediatr Surg 13:31–34
Geoerger B, Hero B, Harms D, et al (2001) Metabolic activity and clinical features of primary ganglioneuromas. Cancer 91:1905–1913
Brodeur GM, Pritchard J, Berthold F, et al (1993) Revisions of the international criteria for diagnosis, staging, and response to treatment in patients with neuroblastoma. J Clin Oncol 11:1466–1477
Brock CE, Ricketts RR (1982) Hemoperitoneum from spontaneous rupture of neonatal neuroblastoma. Am J Dis Child 136:370–371
Nikolic E, Zurga B (1986) Massive adrenal hemorrhage in a neonate due to neuroblastoma. Jugosl Ginekol Perinatol 26:79–81
Vora D, Slovis TL, Boal DK (2000) Hemoperitoneum and disseminated intravascular coagulation in two neonates with congenital bilateral neuroblastoma. Pediatr Radiol 30:394–397
Ingram L, Rivera GK, Shapiro DN (1990) Superior vena cava syndrome associated with childhood malignancy: analysis of 24 cases. Med Pediatr Oncol 18:476–481
Issa PY, Brihi ER, Janin Y, et al (1983) Superior vena cava syndrome in childhood: report of ten cases and review of the literature. Pediatrics 71:337–341
Rheingold SR, Lange BJ (2002) Oncologic emergencies. In: Pizzo PA, Poplack DG (eds) Principles and practice of pediatric oncology. Lippincott Williams and Wilkins, Philadelphia, pp 895–937
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Pinarli, F.G., Danaci, M., Tander, B. et al. Bilateral adrenal cystic neuroblastoma with superior vena cava syndrome and massive intracystic haemorrhage. Pediatr Radiol 34, 746–749 (2004). https://doi.org/10.1007/s00247-004-1209-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00247-004-1209-5