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Oral Albuterol Treatment in Three Pediatric Patients with Bradycardia: A Novel Therapy

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Clinically significant bradycardia is an uncommon problem in children, but one that can cause significant morbidity and sometimes necessitates implantation of a pacemaker. The most common causes of bradycardia are complete heart block (CHB), which can be congenital or acquired, and sinus node dysfunction, which is rare in children with structurally normal hearts. Pacemaker is indicated as therapy for the majority of children with CHB, and while early mortality is lower in postnatally diagnosed CHB than in fetal CHB, it is still up to 16%. In young children, less invasive transvenous pacemaker systems can be technically challenging to place and carry a high risk of complications, often necessitating surgical epicardial pacemaker placement, which usually entails a median sternotomy. We report three cases of pediatric patients referred for pacemaker implantation for different types of bradycardia, treated at our institution with oral albuterol with therapeutic results that avoided the need for surgical pacemaker implantation at that time.

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AB wrote the main manuscript text and prepared the figures. AB and WP performed literature review and compiled the patient histories used for the clinical vignettes. All authors were involved in compiling the patient cases for this series, and reviewed the manuscript.

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Correspondence to Adam M. Butensky.

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Butensky, A.M., Patten, W.F., Silver, E.S. et al. Oral Albuterol Treatment in Three Pediatric Patients with Bradycardia: A Novel Therapy. Pediatr Cardiol 45, 441–445 (2024).

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