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Persistant Left Superior Vena Cava with and Without Right Superior Vena Cava: Significance of Prenatal Diagnosis

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Abstract

This study aims to define the associated anomalies with PLSVC, and to compare single PLSVC and bilateral superior vena cava in terms of accompanying anomalies and pregnancy outcomes. This was a retrospective study of the fetuses diagnosed with single and/or bilateral SVC at a tertiary fetal medicine center during 8 years. We detected 16 cases of single PLSVC and 84 cases of bilateral SVC. We found an association between the PLSVC and cardiac and extracardiac anomalies. Comparison between single PLSVC and BSVC cases revealed significant differences in the occurrence of heterotaxy and right isomerism. The study highlights the importance of prenatal diagnosis in PLSVC cases. Isolated PLSVC with situs solitus may be considered a benign finding, but larger studies are needed to understand the clinical implications of PLSVC in relation to chromosomal anomalies. Routine screening protocols should include three-vessel and trachea views to detect PLSVC.

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Acknowledgements

The authors would like to express our gratitude to all the staff of the Department of Perinatology, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, Health Science University, Istanbul, Turkey, for their support in data collection and analysis.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Perinatology, Zeynep Kamil Women and Children’s Diseases Training and Research Hospital, Health Science University, Uskudar Opr. Dr. Burhanettin Ustunel Cad. No: 10, Istanbul, Turkey

    Ozge Kahramanoglu, Oya Demirci & Lutfiye Uygur

  2. Department of Pediatric Cardiology, Zeynep Kamil Women and Children’s Diseases Training and Research Hospital, Health Science University, Istanbul, Turkey

    Nurdan Erol

  3. Department of Women, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Naples, Italy

    Antonio Schiattarella

  4. Department of Surgical Sciences, Division of Gynecology and Obstetrics, University of Cagliari, Cagliari, Italy

    Agnese Maria Chiara Rapisarda

Authors
  1. Ozge Kahramanoglu
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  2. Oya Demirci
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  3. Lutfiye Uygur
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  4. Nurdan Erol
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  5. Antonio Schiattarella
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  6. Agnese Maria Chiara Rapisarda
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Contributions

OK: Substantial contributions to the conception or design of the work; the acquisition, analysis, interpretation of data for the work, drafting the work or revising it critically for important intellectual content. OD: Analysis of data for the work, Final approval of the version to be published. LU: Revising the work, Final approval of the version to be published. NE: Interpretation of data for the work, Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. AS: Analysis of data for the work, Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. AR: Design of the work, Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All authors reviewed the manuscript.

Corresponding author

Correspondence to Ozge Kahramanoglu.

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Conflict of interest

The authors declare no conflict of interest related to this study.

Ethical Approval

This study was conducted in accordance with the Helsinki Declaration and received approval from the Institutional Review Board (IRB) of the university hospital.

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Kahramanoglu, O., Demirci, O., Uygur, L. et al. Persistant Left Superior Vena Cava with and Without Right Superior Vena Cava: Significance of Prenatal Diagnosis. Pediatr Cardiol 45, 377–384 (2024). https://doi.org/10.1007/s00246-023-03353-0

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  • DOI: https://doi.org/10.1007/s00246-023-03353-0

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