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Hemodynamic Assessment of a Large Pulmonary Arteriovenous Malformation in a Neonate: Case Report and Review of Literature

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Abstract

Herein we report the case of a neonate with a prenatally diagnosed large pulmonary arteriovenous malformation, managed with minimally invasive hemodynamic monitoring in our Neonatal Intensive Care Unit. The combination of Near-Infrared Spectroscopy and Pressure Recording Analytical Method could guide neonatal management of critical cases of vascular anomalies: immediate data are offered to clinicians, from which therapeutic decisions such as timing of surgical resection are made to achieve a positive outcome. We also systemically collected and summarized information on patients’ characteristics of previous cases reported in literature to data, and we compared them to our case.

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Acknowledgements

We sincerely thank Dr. Ee Win Khoo (MD, RANZCR, consultant radiologist at the Queen Elizabeth Hospital Woodville South, Adelaide, South Australia) and Dr. Luca Borro (3D Biomedical Specialist, Clinical Management and Technological Innovations Area, Department of Imaging, Bambino Gesù Children's Hospital, Rome, Italy) for their support.

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Author notes

  1. Paola Giliberti and Domenico Umberto De Rose are first co-authors.

Authors and Affiliations

  1. Neonatal Intensive Care Unit, Medical and Surgical Department of Fetus, Newborn and Infant—“Bambino Gesù” Children’s Hospital IRCCS, 00165, Rome, Italy

    Paola Giliberti, Domenico Umberto De Rose, Francesca Landolfo, Claudia Columbo, Flaminia Pugnaloni, Alessandra Santisi, Natalia Chukhlantseva, Ferdinando Savignoni, Andrea Dotta & Irma Capolupo

  2. Newborn Surgery Unit, Medical and Surgical Department of Fetus, Newborn and Infant—“Bambino Gesù” Children’s Hospital IRCCS, 00165, Rome, Italy

    Andrea Conforti & Pietro Bagolan

  3. Advanced Cardiovascular Imaging Unit, Department of Imaging, “Bambino Gesù” Children’s Hospital IRCCS, 00165, Rome, Italy

    Aurelio Secinaro

  4. Department of Pathology, “Bambino Gesù” Children’s Hospital IRCCS, 00165, Rome, Italy

    Paola Francalanci

  5. Department of Anesthesia and Critical Care, “Bambino Gesù” Children’s Hospital IRCCS, 00165, Rome, Italy

    Patrizia Bozza

  6. Fetal Medicine and Surgery Unit, Medical and Surgical Department of Fetus, Newborn and Infant—“Bambino Gesù” Children’s Hospital IRCCS, 00165, Rome, Italy

    Leonardo Caforio

  7. Perinatal Cardiology Unit, Medical and Surgical Department of Fetus, Newborn and Infant—“Bambino Gesù” Children’s Hospital IRCCS, 00165, Rome, Italy

    Alessandra Toscano

  8. Medical Genetics Laboratory, “Bambino Gesù” Children’s Hospital IRCCS, 00165, Rome, Italy

    Antonio Novelli

Authors
  1. Paola Giliberti
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  2. Domenico Umberto De Rose
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  3. Francesca Landolfo
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Contributions

PG and DUDR conceptualized and designed the study, drafted the initial manuscript, participated to the case management, collected data, performed literature search, carried out the initial analyses and reviewed and revised the manuscript. FL, CC, FP, ASa performed literature search, collected and interpreted data, and revised the manuscript. AC and PBa performed surgical repair, and critically reviewed the manuscript for important intellectual content. ASe, LC and AT performed imaging (computed tomography, prenatal ultrasound and echocardiography, respectively), and revised the manuscript. AN performed genetic analysis and revised the manuscript. PF performed histopathological studies and revised the manuscript. PBo, NC and FS participated to the case management and revised the manuscript. AD and IC coordinated and supervised data collection, and critically reviewed the manuscript for important intellectual content. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

Corresponding author

Correspondence to Francesca Landolfo.

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Conflict of interest

The authors have no conflict of interest to disclose.

Ethical Approval

Considering the nature of the analysis, this study reported only a retrospective analysis of data available through the Institutional Database. Personal data were restricted to essential information and were treated in order to guarantee the respect of privacy of the involved patients, as specifically stated by Italian Law D.Lgs n.196 of 2003 about personal data protection. Therefore, the study did not require preliminary evaluation by the local Ethical Committee.

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Giliberti, P., De Rose, D.U., Landolfo, F. et al. Hemodynamic Assessment of a Large Pulmonary Arteriovenous Malformation in a Neonate: Case Report and Review of Literature. Pediatr Cardiol 43, 1383–1391 (2022). https://doi.org/10.1007/s00246-022-02862-8

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