Skip to main content

Advertisement

SpringerLink
Log in

Endovascular Repair of a Descending Thoracic Aortic Aneurysm in a Pediatric Patient with Tuberous Sclerosis: A Case Report and Review of the Literature

  • Case Report
  • Published:
Pediatric Cardiology Aims and scope Submit manuscript

Abstract

Aortic aneurysm in children is rare, but has been described in the tuberous sclerosis complex (TSC) population. While surgical repair has been utilized as the primary means of intervention, we present the first known case reporting exclusion of a descending thoracic aortic aneurysm with percutaneous covered stent implantation in a pediatric patient with TSC. A review of the literature is also included herein.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Randle SC (2017) Tuberous sclerosis complex: a review. Pediatr Ann 46(4):e166–e171

    Article  Google Scholar 

  2. Weiner DM et al (1998) The tuberous sclerosis complex: a comprehensive review. J Am Coll Surg 187(5):548–561

    Article  CAS  Google Scholar 

  3. Rosser T, Panigrahy A, McClintock W (2006) The diverse clinical manifestations of tuberous sclerosis complex: a review. Semin Pediatr Neurol 13(1):27–36

    Article  Google Scholar 

  4. Freycon F et al (1971) Abdominal aorta aneurysm during Bourneville’s tuberous sclerosis. Pediatrie 26(4):421–427

    CAS  PubMed  Google Scholar 

  5. Larbre F et al (1971) Clinical and anatomical case of an aortic aneurysm in the course of Bourneville’s tuberous sclerosis. Arch Fr Pediatr 28(9):975–984

    CAS  PubMed  Google Scholar 

  6. Dutton RV, Singleton EB (1975) Tuberous sclerosis: a case report with aortic aneurysm and unusual rib changes. Pediatr Radiol 3(3):184–186

    Article  CAS  Google Scholar 

  7. Hagood CO Jr et al (1976) Abdominal aortic aneurysm and renal hamartoma in an infant with tuberous sclerosis. Surgery 79(6):713–715

    PubMed  Google Scholar 

  8. Rolfes DB, Towbin R, Bove KE (1985) Vascular dysplasia in a child with tuberous sclerosis. Pediatr Pathol 3(2–4):359–373

    Article  CAS  Google Scholar 

  9. Towbin RB, Ball WS, Kaufman RA (1987) Pediatric case of the day: abdominal aortic aneurysm in a patient with tuberous sclerosis. Radiographics 7(4):818–821

    Article  CAS  Google Scholar 

  10. van Reedt Dortland RW, Bax NM, Huber J (1991) Aortic aneurysm in a 5-year-old boy with tuberous sclerosis. J Pediatr Surg 26(12):1420–1422

    Article  Google Scholar 

  11. Lavocat MP et al (1992) Abdominal aortic aneurysm and Bourneville’s tuberous sclerosis. Pediatrie 47(7–8):517–519

    CAS  PubMed  Google Scholar 

  12. Shepherd CW et al (1991) Causes of death in patients with tuberous sclerosis. Mayo Clin Proc 66(8):792–796

    Article  CAS  Google Scholar 

  13. Tsukui A et al (1995) Aortic aneurysm in a four-year-old child with tuberous sclerosis. Paediatr Anaesth 5(1):67–70

    Article  CAS  Google Scholar 

  14. Paraf F, Bruneval P (1996) Arterial fibromuscular dysplasia and Bourneville’s tuberous sclerosis. Ann Pathol 16(3):203–206

    CAS  PubMed  Google Scholar 

  15. Tamisier D et al (1997) Abdominal aortic aneurysm in a child with tuberous sclerosis. Ann Vasc Surg 11(6):637–639

    Article  CAS  Google Scholar 

  16. Bavdekar SB et al (2000) Aortic aneurysm in a child with tuberous sclerosis. Indian Pediatr 37(3):319–322

    CAS  PubMed  Google Scholar 

  17. Jost CJ et al (2001) Aortic aneurysms in children and young adults with tuberous sclerosis: report of two cases and review of the literature. J Vasc Surg 33(3):639–642

    Article  CAS  Google Scholar 

  18. Patino Bahena E et al (2005) Giant aortic aneurysm and rhabdomyomas in infant with tuberous sclerosis (case report). Arch Cardiol Mex 75(4):448–450

    PubMed  Google Scholar 

  19. Kimura Y et al (2005) A case of 2-year-old boy with tuberous sclerosis complicated with descending aortic aneurysm. Pediatr Int 47(2):224–226

    Article  Google Scholar 

  20. Wong H et al (2006) Management of severe hypertension in a child with tuberous sclerosis-related major vascular abnormalities. J Hypertens 24(3):597–599

    Article  CAS  Google Scholar 

  21. Moon SB et al (2009) An abdominal aortic aneurysm in an 8-month-old girl with tuberous sclerosis. Eur J Vasc Endovasc Surg 37(5):569–571

    Article  Google Scholar 

  22. Salerno AE et al (2010) Vascular involvement in tuberous sclerosis. Pediatr Nephrol 25(8):1555–1561

    Article  Google Scholar 

  23. Ye C et al (2012) Abdominal aorta aneurysms in children: single-center experience of six patients. Ann Thorac Surg 93(1):201–205

    Article  Google Scholar 

  24. Sawan EB et al (2015) Successful operation for thoracoabdominal aortic aneurysm in a 5-year-old boy with tuberous sclerosis. Ann Thorac Surg 100(5):e119–e120

    Article  Google Scholar 

  25. Eliason JL et al (2016) Surgical treatment of abdominal aortic aneurysms in infancy and early childhood. J Vasc Surg 64(5):1252–1261

    Article  Google Scholar 

  26. Dueppers P et al (2017) Open repair for abdominal aortic aneurysm in a young boy with tuberous sclerosis and review of the literature. Ann Vasc Surg 39:2861–2865

    Article  Google Scholar 

  27. Geiger MA, Cantador AA, Guillaumon AT (2019) Thoracic aortic aneurysm in a patient with tuberous sclerosis. J Vasc Bras 18:e20160017

    Article  Google Scholar 

  28. Andrassy J et al (2011) Endovascular versus open treatment of degenerative aneurysms of the descending thoracic aorta: a single center experience. Vascular 19(1):8–14

    Article  Google Scholar 

  29. Holzer RJ et al (2021) Long-term outcomes of the coarctation of the aorta stent trials. Circ Cardiovasc Interv 14(6):e010308

    Article  CAS  Google Scholar 

  30. Svensson LG et al (2008) Expert consensus document on the treatment of descending thoracic aortic disease using endovascular stent-grafts. Ann Thorac Surg 85(1 Suppl):S1-41

    Article  Google Scholar 

  31. Uchida N (2014) How to prevent spinal cord injury during endovascular repair of thoracic aortic disease. Gen Thorac Cardiovasc Surg 62(7):391–397

    Article  Google Scholar 

  32. Greenberg RK et al (2008) Contemporary analysis of descending thoracic and thoracoabdominal aneurysm repair: a comparison of endovascular and open techniques. Circulation 118(8):808–817

    Article  Google Scholar 

  33. Waters KM et al (2017) Histopathologic differences partially distinguish syndromic aortic diseases. Cardiovasc Pathol 30:6–11

    Article  Google Scholar 

  34. Cao J et al (2010) Thoracic aortic disease in tuberous sclerosis complex: molecular pathogenesis and potential therapies in Tsc2+/- mice. Hum Mol Genet 19(10):1908–1920

    Article  CAS  Google Scholar 

  35. Conway AM et al (2020) Endovascular abdominal aortic aneurysm repair in patients with Marfan syndrome. Vascular 28(1):48–52

    Article  Google Scholar 

  36. Pellenc Q et al (2020) Optimising aortic endovascular repair in patients with marfan syndrome. Eur J Vasc Endovasc Surg 59(4):577–585

    Article  Google Scholar 

  37. Hosn MA et al (2017) Endovascular Treatment of a Traumatic Thoracic Aortic Injury in an Eight-Year Old Patient: Case Report and Review of Literature. Ann Vasc Surg 39:2921–2924

    Article  Google Scholar 

  38. Juszkat R et al (2013) Endovascular treatment of late thoracic aortic aneurysms after surgical repair of congenital aortic coarctation in childhood. PLoS ONE 8(12):e83601

    Article  Google Scholar 

  39. Kotelis D et al (2016) Endovascular repair of pseudoaneurysms after open surgery for aortic coarctation. Interact Cardiovasc Thorac Surg 22(1):26–31

    Article  Google Scholar 

  40. Taggart NW et al (2016) Immediate outcomes of covered stent placement for treatment or prevention of aortic wall injury associated with coarctation of the aorta (COAST II). JACC Cardiovasc Interv 9(5):484–493

    Article  Google Scholar 

Download references

Funding

No funding was received to assist with the preparation of this manuscript.

Author information

Authors and Affiliations

  1. Charles E. Mullins Cardiac Catheterization Laboratories, Texas Children’s Hospital, and Lillie Frank and Abercrombie Section of Cardiology, Department of Pediatrics, Baylor College of Medicine, 6651 Main Street Suite E-1920, Houston, TX, 77025, USA

    Ryan D. Byrne, Subhrajit Lahiri, Manish Bansal, Benjamin Jacob & Gary Stapleton

Authors
  1. Ryan D. Byrne
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Subhrajit Lahiri
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Manish Bansal
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Benjamin Jacob
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gary Stapleton
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ryan D. Byrne.

Ethics declarations

Conflicts of interest

There are no relevant financial or non-financial interests to disclose.

Ethical Approval

This article does not contain any studies with human participants or animals performed by the authors.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Byrne, R.D., Lahiri, S., Bansal, M. et al. Endovascular Repair of a Descending Thoracic Aortic Aneurysm in a Pediatric Patient with Tuberous Sclerosis: A Case Report and Review of the Literature. Pediatr Cardiol 43, 238–243 (2022). https://doi.org/10.1007/s00246-021-02717-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00246-021-02717-8

Keywords

Search

Navigation