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Pacemaker Implantation in Neonates and Infants: Favorable Outcomes with Epicardial Pacing Systems

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Abstract

The implantation of pacemakers (PM) in neonates and infants requires particular consideration of small body size, marked body growth potential, and the decades of future pacing therapy to be expected. The aim of this study is to quantify the complications of implantation and outcome occurring at our center and to compare these with other centers. Retrospective analysis of 52 consecutive patients undergoing PM implantation at a single tertiary care center within the first year of life. PMs were implanted at a median age of 3 months (range 0–10 months). Structural heart defects were present in 44 of 52 patients. During a median follow-up time of 40.4 months (range 0.1–114 months), measurements for sensing, pacing thresholds, and lead impedance remained stable. No adverse pacing effect was observed in left ventricular function or dimensions over time. There were 20 reoperations in 13 patients at a median time of 4.7 years (range 0.05–8.2 years) after implantation, for end of battery life (n = 10), lead dysfunction (n = 3), device dislocation (n = 3), infection (n = 3), and diaphragmatic paresis (n = 1). No PM-related mortality occurred. Epicardial pacemaker implantation in neonates and infants is an invasive but safe and effective procedure with a relatively low risk of complications. Our current implantation technique and the use of bipolar steroid-eluting electrodes, which we prefer to implant on the left ventricular apex, lead to favorable long-term results.

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References

  1. Singh HR, Batra AS, Balaji S (2013) Pacing in children. Ann Pediatr Cardiol 6:46–51

    Article  Google Scholar 

  2. Kertesz NJ, Fenrich AL, Friedman RA (1997) Congenital complete atrioventricular block. Tex Heart Inst J 24:301–307

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, Cleland J, Deharo JC, Delgado V, Elliott PM, Gorenek B, Israel CW, Leclercq C, Linde C, Mont L, Padeletti L, Sutton R, Vardas PE (2013) 2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: the task force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Europace 15:1070–1118

    Article  Google Scholar 

  4. Vos LM, Kammeraad JAE, Freund MW, Blank AC, Breur JMPJ (2017) Long-term outcome of transvenous pacemaker implantation in infants: a retrospective cohort study. Europace 19:581–587

    PubMed  Google Scholar 

  5. Gebauer RA, Tomek V, Salameh A, Marek J, Chaloupecký V, Gebauer R, Matejka T, Vojtovic P, Janousek J (2009) Predictors of left ventricular remodelling and failure in right ventricular pacing in the young. Eur Heart J 30:1097–1104

    Article  Google Scholar 

  6. Epstein AE, Dimarco JP, Ellenbogen KA, Estes NA 3rd, Freedman RA, Gettes LS, Gillinov AM, Gregoratos G, Hammill SC, Hayes DL, Hlatky MA, Newby LK, Page RL, Schoenfeld MH, Silka MJ, Stevenson LW, Sweeney MO (2008) American College of Cardiology; American Heart Association Task Force on Practice Guidelines; American Association for Thoracic Surgery; Society of Thoracic Surgeons. ACC/AHA/HRS 2008 Guidelines for device-based therapy of cardiac rhythm abnormalities. Heart Rhythm 5:e1–62

    Article  Google Scholar 

  7. Bauersfeld U, Przibille O, Gajic Z, Fåhraeus T, Kampmann C, Rahn-Schönbeck M, Schüller H (2001) Alternative to the transvenous approach in pediatric pacing: long-term experiences with bipolar epicardial pacing leads. Herzschrittmacherther Elektrophysiol 12:158–162

    Article  CAS  Google Scholar 

  8. Cohen MI, Bush DM, Vetter VL, Tanel RE, Wieand TS, Gaynor JW, Rhodes LA (2001) Permanent epicardial pacing in pediatric patients: seventeen years of experience and 1200 outpatient visits. Circulation 103:2585–2590

    Article  CAS  Google Scholar 

  9. Silvetti MS, Drago F, Grutter G, De Santis A, Di Ciommo V, Ravà L (2006) Twenty years of paediatric cardiac pacing: 515 pacemakers and 480 leads implanted in 292 patients. Europace 8:530–536

    Article  Google Scholar 

  10. Kubus P, Materna O, Gebauer RA, Matejka T, Gebauer R, Tláskal T, Janousek J (2012) Permanent epicardial pacing in children: long-term results and factors modifying outcome. Europace 14(4):509–514

    Article  Google Scholar 

  11. van Geldorp IE, Delhaas T, Gebauer RA, Frias P, Tomaske M, Friedberg MK, Tisma-Dupanovic S, Elders J, Früh A, Gabbarini F, Kubus P, Illikova V, Tsao S, Blank AC, Hiippala A, Sluysmans T, Karpawich P, Clur SA, Ganame X, Collins KK, Dann G, Thambo JB, Trigo C, Nagel B, Papagiannis J, Rackowitz A, Marek J, Nürnberg JH, Vanagt WY, Prinzen FW, Janousek J, Working Group for Cardiac Dysrhythmias, and Electrophysiology of the Association for European Paediatric Cardiology (2011) Impact of the permanent ventricular pacing site on left ventricular function in children: a retrospective multicentre survey. Heart. 97:2051–2055

    Article  Google Scholar 

  12. Janoušek J, van Geldorp IE, Krupičková S, Rosenthal E, Nugent K, Tomaske M, Früh A, Elders J, Hiippala A, Kerst G, Gebauer RA, Kubuš P, Frias P, Gabbarini F, Clur SA, Nagel B, Ganame J, Papagiannis J, Marek J, Tisma-Dupanovic S, Tsao S, Nürnberg JH, Wren C, Friedberg M, de Guillebon M, Volaufova J, Prinzen FW, Delhaas T, Working Group for Cardiac Dysrhythmias, and Electrophysiology of the Association for European Pediatric Cardiology (2013) Permanent cardiac pacing in children: choosing the optimal pacing site: a multicenter study. Circulation. 127:613–623

    Article  Google Scholar 

  13. Silvetti MS, Di Carlo D, Ammirati A, Placidi S, Di Mambro C, Ravà L, Drago F (2015) Left ventricular pacing in neonates and infants with isolated congenital complete or advanced atrioventricular block: short- and medium-term outcome. Europace 17:603–610

    Article  Google Scholar 

  14. Carreras EM, Duncan WJ, Djurdjev O, Campbell AI (2015) Cardiac strangulation following epicardial pacemaker implantation: a rare pediatric complication. J Thorac Cardiovasc Surg 149:522–527

    Article  Google Scholar 

  15. Fortescue EB, Berul CI, Cecchin F, Walsh EP, Triedman JK, Alexander ME (2004) Patient, procedural, and hardware factors associated with pacemaker lead failures in pediatrics and congenital heart disease. Heart Rhythm 1:150–159

    Article  Google Scholar 

  16. Villain E, Martelli H, Bonnet D, Iserin L, Butera G, Kachaner J (2000) Characteristics and results of epicardial pacing in neonates and infants. Pacing Clin Electrophysiol 23:2052–2056

    Article  CAS  Google Scholar 

  17. Aellig NC, Balmer C, Dodge-Khatami A, Rahn M, Prêtre R, Bauersfeld U (2007) Long-term follow-up after pacemaker implantation in neonates and infants. Ann Thorac Surg 83:1420–1423

    Article  Google Scholar 

  18. Kwak JG, Kim SJ, Song JY, Choi EY, Lee SY, Shim WS, Lee CH, Lee C, Park CS (2012) Permanent epicardial pacing in pediatric patients: 12-year experience at a single center. Ann Thorac Surg 93:634–639

    Article  Google Scholar 

  19. Horenstein MS, Karpawich PP, Tantengco MV (2003) Single versus dual chamber pacing in the young: noninvasive comparative evaluation of cardiac function. Pacing Clin Electrophysiol 26:1208–1211

    Article  Google Scholar 

  20. Chaouki AS, Spar DS, Khoury PR, Anderson JB, Knilans TK, Morales DL, Czosek RJ (2017) Risk factors for complications in the implantation of epicardial pacemakers in neonates and infants. Heart Rhythm 14:206–210

    Article  Google Scholar 

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Correspondence to Christian Balmer.

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Wildbolz, M., Dave, H., Weber, R. et al. Pacemaker Implantation in Neonates and Infants: Favorable Outcomes with Epicardial Pacing Systems. Pediatr Cardiol 41, 910–917 (2020). https://doi.org/10.1007/s00246-020-02332-z

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  • DOI: https://doi.org/10.1007/s00246-020-02332-z

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