Abstract
The purpose of this study is to evaluate post-operative length of stay (LOS) following surgical repair of congenital heart defects (CHD) and to investigate baseline pre-operative factors and predictors of post-operative LOS (pLOS). Retrospective chart review of all cases of corrective surgery for CHD performed at the Pediatric Cardiology Unit, King Abdulaziz University Hospital, Jeddah during January 2013—December 2016. Baseline demographics, clinical factors, pre-operative, intra-operative, post-operative cardiac and extra-cardiac complications were analyzed as independent factors of pLOS using stepwise linear regression. Kaplan–Meier (KM) survival analysis was used to analyze the correlation of pLOS (in days) with the independent variables and estimate the probability to exceeding a given pLOS. A total 191 patients (52.4% male, 49.7% aged ≤ 1 year) were included with a median [range] LOS = 10 [3, 158] days. Several baseline clinical factors were associated with longer pLOS such as complex CHD types (tetralogy of Fallot, transposition of great arteries, etc.), high-risk RACHS categories and low weight at surgery. Independent risk factors of pLOS included pre-operative hemoglobin level (unstandardized regression coefficient: B = 2.96, p = 0.036) as the only pre-operative predictor of LOS, besides intra-operative complications (B = 11.72, p = 0.009) and posto-perative factors including MV duration (B = 9.39, p < 0.001), diet/feeding problems (B = 10.27, p = 0.001) and drain tube stay (B = 3.82, p = 0.003). KM survival curves confirmed that these factors increased the probability for longer LOS. Post-operative LOS was associated with several baseline and peri-operative factors; however, it was independently predicted by abnormal baseline hemoglobin level, the occurrence of intra-operative complications, besides post-operative feeding problems, chest drain stay, and MV duration.
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References
Hoffman JIE (2013) The global burden of congenital heart disease. Cardiovasc J Afr 24(4):141–145
Azhar A, AlShammasi Z, Higgi R (2016) The impact of congenital heart diseases on the quality of life of patients and their families in Saudi Arabia. Biological, psychological, and social dimensions. Saudi Med J 37(4):392–402. http://www.smj.org.sa/index.php/smj/article/view/smj.2016.4.13626/7995
Oster ME, Riehle-Colarusso T, Simeone RM, Gurvitz M, Kaltman JR, McConnell M et al (2013) Public health science agenda for congenital heart defects: report from a centers for disease control and prevention experts meeting. J Am Heart Assoc 2(5):e000256. https://doi.org/10.1161/JAHA.113.000256
Centers for Disease Control and Prevention (2009) Compressed mortality file: underlying cause of death, 1979 to 2006. http://wonder.cdc.gov/%0AmortSQl.html
Mazor Dray E, Marelli AJ (2015) Adult congenital heart disease. Cardiol Clin 33(4):503–512. http://linkinghub.elsevier.com/retrieve/pii/S0733865115000703
van der Bom T, Zomer AC, Zwinderman AH, Meijboom FJ, Bouma BJ, Mulder BJM (2011) The changing epidemiology of congenital heart disease. Nat Rev Cardiol 8(1):50–60. https://doi.org/10.1038/nrcardio.2010.166
Amirah MA, Nada MA, Anna A, Mowafa SH, Ashraf E (2015) The epidemiology of congenital heart diseases in Saudi Arabia: a systematic review. J Public Heal Epidemiol 7(7):232–240. http://academicjournals.org/journal/JPHE/article-abstract/383732E53771
Al-Mesned A, Al Akhfash AA, Sayed M (2012) Incidence of severe congenital heart disease at the Province of Al-Qassim, Saudi Arabia. Congenit Heart Dis 7(3):277–282. https://doi.org/10.1111/j.1747-0803.2011.00614.x
Al-Aama JY, Bondagji NS, El-Harouni AA (2012) Congenital heart defects in down syndrome patients from western Saudi Arabia. Saudi Med J 33(11):1211–1215
Alqurashi M, El Mouzan M, Al Herbish A, Al Salloum A, Al Omer A (2007) Symptomatic congenital heart disease in the Saudi children and adolescents project. Ann Saudi Med 27(6):442–444. http://www.annsaudimed.net/index.php/vol27/vol27iss6/406.html
Alabdulgader AAA (2006) Congenital heart disease in Saudi Arabia: current epidemiology and future projections. East Mediterr Health J 12(Suppl 2):S157–S167. http://www.ncbi.nlm.nih.gov/pubmed/17361687
Majeed-Saidan MA, Ammari AN, AlHashem AM, Al Rakaf MS, Shoukri MM, Garne E et al (2015) Effect of consanguinity on birth defects in Saudi women: results from a nested case-control study. Birth Defects Res A 103(2):100–104. https://doi.org/10.1002/bdra.23331
Hoffman JI, Kaplan S (2002) The incidence of congenital heart disease. J Am Coll Cardiol 39(12):1890–1900. http://linkinghub.elsevier.com/retrieve/pii/S0735109702018867
El Mouzan M, Al Salloum A, Al Herbish A, Qurachi M, Al Omar A (2008) Consanguinity and major genetic disorders in Saudi children: a community-based cross-sectional study. Ann Saudi Med 28(3):169
Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G et al (2010) Heart disease and stroke statistics—2010 update: a report from the American Heart Association. Circulation 121(7):e46–e215. https://doi.org/10.1161/CIRCULATIONAHA.109.192667
Bergersen L, Brennan A, Gauvreau K, Connor J, Almodovar M, DiNardo J et al (2015) A method to account for variation in congenital heart surgery charges. Ann Thorac Surg 99(3):939–946. http://www.ncbi.nlm.nih.gov/pubmed/25620593
Russo CA, Elixhauser A (2006) Hospitalizations for birth defects, 2004: statistical Brief #24. Healthcare Cost and Utilization Project (HCUP) statistical briefs. http://www.ncbi.nlm.nih.gov/pubmed/21938840
Brennan A, Gauvreau K, Connor J, Almodovar M, DiNardo J, Banka P et al (2017) A method to account for variation in congenital heart surgery length of stay. Pediatr Crit Care Med 18(6):550–560. http://www.ncbi.nlm.nih.gov/pubmed/28437365
Larsen SH, Pedersen J, Jacobsen J, Johnsen SP, Hansen OK, Hjortdal V (2005) The RACHS-1 risk categories reflect mortality and length of stay in a Danish population of children operated for congenital heart disease. Eur J Cardiothorac Surg 28(6):877–881. http://www.ncbi.nlm.nih.gov/pubmed/16242940
Simsic JM, Cuadrado A, Kirshbom PM, Kanter KR (2006) Risk adjustment for congenital heart surgery (RACHS): is it useful in a single-center series of newborns as a predictor of outcome in a high-risk population? Congenit Heart Dis 1(4):148–151. http://www.ncbi.nlm.nih.gov/pubmed/18377539
Meijboom F, Mulder B (2010) Problems in the organization of care for patients with adult congenital heart disease. Arch Cardiovasc Dis 103(6–7):411–415. http://linkinghub.elsevier.com/retrieve/pii/S1875213610001129
Pasquali SK, He X, Jacobs ML, Shah SS, Peterson ED, Gaies MG et al (2014) Excess costs associated with complications and prolonged length of stay after congenital heart surgery. Ann Thorac Surg 98(5):1660–1666. http://linkinghub.elsevier.com/retrieve/pii/S0003497514013150
Kempny A, Dimopoulos K, Uebing A, Diller G-P, Rosendahl U, Belitsis G et al (2017) Outcome of cardiac surgery in patients with congenital heart disease in England between 1997 and 2015. PLoS ONE 12(6):e0178963
Goepfert MSG, Reuter DA, Akyol D, Lamm P, Kilger E, Goetz AE (2007) Goal-directed fluid management reduces vasopressor and catecholamine use in cardiac surgery patients. Intensive Care Med 33(1):96–103. https://doi.org/10.1007/s00134-006-0404-2
Duque-Sosa P, Martínez-Urbistondo D, Echarri G, Callejas R, Iribarren MJ, Rábago G et al (2017) Perioperative hemoglobin area under the curve is an independent predictor of renal failure after cardiac surgery. Results from a Spanish multicenter retrospective cohort study. PLoS ONE 12(2):e0172021. https://doi.org/10.1371/journal.pone.0172021
Anderson JB, Beekman RH, Border WL, Kalkwarf HJ, Khoury PR, Uzark K et al (2009) Lower weight-for-age z score adversely affects hospital length of stay after the bidirectional Glenn procedure in 100 infants with a single ventricle. J Thorac Cardiovasc Surg 138(2):397–404.e1. http://linkinghub.elsevier.com/retrieve/pii/S0022522309003699
Toole BJ, Toole LE, Kyle UG, Cabrera AG, Orellana RA, Coss-Bu JA. Perioperative nutritional support and malnutrition in infants and children with congenital heart disease. Congenit Heart Dis 9(1):15–25. http://www.ncbi.nlm.nih.gov/pubmed/23602045
Connor JA (2005) Factors associated with increased resource utilization for congenital heart disease. Pediatrics 116(3):689–695. https://doi.org/10.1542/peds.2004-2071
Benavidez OJ, Gauvreau K, Del Nido P, Bacha E, Jenkins KJ (2007) Complications and risk factors for mortality during congenital heart surgery admissions. Ann Thorac Surg 84(1):147–155. http://linkinghub.elsevier.com/retrieve/pii/S0003497507004055
Johnson EA, Zubair MM, Armsby LR, Burch GH, Good MK, Lasarev MR et al (2016) Surgical quality predicts length of stay in patients with congenital heart disease. Pediatr Cardiol 37(3):593–600. https://doi.org/10.1007/s00246-015-1319-x
Benavidez OJ, Connor JA, Gauvreau K, Jenkins KJ (2007) The contribution of complications to high resource utilization during congenital heart surgery admissions. Congenit Heart Dis 2(5):319–326. https://doi.org/10.1111/j.1747-0803.2007.00119.x
Agarwal HS, Wolfram KB, Saville BR, Donahue BS, Bichell DP (2014) Postoperative complications and association with outcomes in pediatric cardiac surgery. J Thorac Cardiovasc Surg 148(2):609–16.e1. http://www.ncbi.nlm.nih.gov/pubmed/24280709
Pasquali SK, He X, Jacobs JP, Jacobs ML, O’Brien SM, Gaynor JW (2012) Evaluation of failure to rescue as a quality metric in pediatric heart surgery: an analysis of the STS Congenital Heart Surgery Database. Ann Thorac Surg 94(2):573–579. http://www.ncbi.nlm.nih.gov/pubmed/22633496 discussion 579 – 80.
Kansy A, Tobota Z, Maruszewski P, Maruszewski B (2010) Analysis of 14,843 neonatal congenital heart surgical procedures in the European Association for Cardiothoracic Surgery Congenital Database. Ann Thorac Surg 89(4):1255–1259. http://www.ncbi.nlm.nih.gov/pubmed/20338347
Rekawek J, Kansy A, Miszczak-Knecht M, Manowska M, Bieganowska K, Brzezinska-Paszke M et al (2007) Risk factors for cardiac arrhythmias in children with congenital heart disease after surgical intervention in the early postoperative period. J Thorac Cardiovasc Surg 133(4):900–904. http://www.ncbi.nlm.nih.gov/pubmed/17382623
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Authors declare having no proprietary, financial, professional, or any other personal interest of any nature or kind in any product or services and/or company that could be construed or considered to be a potential conflict of interest that might have influenced the views that are expressed in this manuscript. Author received no financial support for this study.
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This study was approved by the institutional review board of King Abdulaziz University. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Azhar, A.S., Aljefri, H.M. Predictors of Extended Length of Hospital Stay Following Surgical Repair of Congenital Heart Diseases. Pediatr Cardiol 39, 1688–1699 (2018). https://doi.org/10.1007/s00246-018-1953-1
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DOI: https://doi.org/10.1007/s00246-018-1953-1