Prognostic Value of Serum Apelin Level in Children with Heart Failure Secondary to Congenital Heart Disease
- 127 Downloads
Apelin is an endogenous inotrope that decreased in heart failure (HF). We aimed to evaluate the prognostic value of its level in children with HF due to congenital heart disease (CHD). Sixty children with HF due to CHD were included as a patient group. Sixty healthy children matched for age, sex, and weight served as a control group. Chest X-ray, electrocardiogram (ECG), echocardiography, and laboratory investigations such as complete blood count, c-reactive protein, and serum apelin levels were performed for all included children at admission. All children were followed up for 3 months. Serum apelin level was significantly decreased in patients with HF at admission than healthy control group and this decrease went with advanced stage of HF. Serum apelin levels were significantly decreased in patients with unfavorable prognosis than those with favorable prognosis. At a cutoff lower than 126 ng/l, the sensitivity of serum apelin to predict unfavorable prognosis in children with HF was 96% with a specificity of 82%. Serum apelin level had a significant positive correlation with left ventricular systolic function (P < 0.05). Moreover, it had a significant negative correlation with heart rate, respiratory rate, Ross classification, c-reactive protein, cardiothoracic ratio, and both left and right ventricular dimensions (P < 0.05). Serum apelin level has a good predictive value for adverse outcome in children with HF due to CHD.
KeywordsChildren Serum apelin Prognosis Heart failure
Compliance with Ethical Standards
Conflict of interest
All authors have no potential conflict of interest to disclose.
The study is in accordance with the ethical standards of institutional research committee and with the 1964 Helsinki declaration and its later amendments.
Informed consents were obtained from all individual participants included in the study.
- 9.Goidescu CM, Anton FP, Leucuța DC, Mircea PA, Vida-Simiti LA (2016) Serum level of apelin-13 negatively correlated with NT-pro BNP in heart failure patients. Rev Rom Med Lab 24(4):399–412Google Scholar
- 10.van Kimmenade RR, Januzzi JL Jr, Ellinor PT, Sharma UC, Bakker JA, Low AF, Martinez A, Crijns HJ, MacRae CA, Menheere PP, Pinto YM (2006) Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol 48:1217–1224CrossRefPubMedGoogle Scholar
- 13.Chen MM, Ashley EA, Deng DX, Tsalenko A, Deng A, Tabibiazar R, Ben-Dor A, Fenster B, Yang E, King JY, Fowler M, Robbins R, Johnson FL, Bruhn L, McDonagh T, Dargie H, Yakhini Z, Tsao PS, Quertermous T et al (2003) Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation 108:1432–1439CrossRefPubMedGoogle Scholar