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Pediatric Cardiology

, Volume 39, Issue 5, pp 1023–1030 | Cite as

A Novel Mechanism for Improved Exercise Performance in Pediatric Fontan Patients After Cardiac Rehabilitation

  • Samuel Wittekind
  • Wayne Mays
  • Yvette Gerdes
  • Sandra Knecht
  • John Hambrook
  • William Border
  • John Lynn Jefferies
Original Article

Abstract

Patients with a Fontan circulation have impaired exercise capacity. Cardiac rehabilitation (CR) has shown promise in enhancing peak exercise parameters in this population, but an improvement in submaximal exercise has not been consistently demonstrated. We assessed the hypothesis that participation in CR will be associated with more efficient oxygen extraction and ventilation during submaximal exercise. In this prospective study, pediatric Fontans completed two 60 min CR sessions per week for 12 weeks. Cardiopulmonary exercise testing and stress echocardiography were performed at baseline and last CR session, and then compared with a paired sample t test. Ten pediatric Fontans completed the study. Five had tricuspid atresia and five had hypoplastic left heart syndrome. No serious adverse events occurred during CR sessions. Peak indexed oxygen consumption increased by a mean of 3.7 mL/kg/min (95% CI 1.5–5.9; p = 0.004), and peak oxygen pulse increased by a mean of 0.9 mL/beat (95% CI 0.4–1.4; p = 0.004). The peak respiratory exchange ratio did not change significantly. The significant difference in oxygen pulse became evident during submaximal exercise without a corresponding difference in echocardiographic stroke volume. Indexed oxygen consumption at ventilatory anaerobic threshold increased by a mean of 3.0 mL/kg/min (95% CI − 0.07 to 6.0; p = 0.055). The slope for the volume of expired ventilation to volume of carbon dioxide production improved by a mean of 4.5 (95% CI − 8.4 to − 0.6; p = 0.03). We observed significant improvements in both submaximal and peak exercise performance in pediatric Fontans undergoing CR with no serious adverse events. These changes appeared to be mediated, at least in part, by more efficient oxygen extraction and ventilation.

Keywords

Cardiac rehabilitation Exercise therapy Exercise testing Fontan circulation Congenital heart disease 

Notes

Compliance with Ethical Standards

Conflict of interest

Samuel Wittekind, Wayne Mays, Yvette Gerdes, Sandra Knecht, John Hambrook, William Border, and John Lynn Jefferies declare that they have no conflicts of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Samuel Wittekind
    • 1
  • Wayne Mays
    • 1
  • Yvette Gerdes
    • 1
  • Sandra Knecht
    • 1
  • John Hambrook
    • 1
  • William Border
    • 2
  • John Lynn Jefferies
    • 1
  1. 1.Cincinnati Children’s Hospital Medical CenterHeart InstituteCincinnatiUSA
  2. 2.Children’s Healthcare of AtlantaEmory University School of MedicineAtlantaUSA

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