Pediatric Cardiology

, Volume 39, Issue 4, pp 705–708 | Cite as

Persistent Pulmonary Hypertension and Histologic Chorioamnionitis in Preterm Infants: Controlled Study

  • N. Katz
  • Y. Bar-Or
  • A. Raucher-Sterrnfeld
  • A. Tamir
  • D. Kohelet
Original Article


Persistent pulmonary hypertension (PPHN) of the newborn is one of the most challenging acute disorders of postnatal transition with substantial morbidity and mortality. The aim of the study was to find if there is an association between persistent pulmonary hypertension and histologic chorioamnionitis in preterm infants. 27 preterm infants with echocardiographic evidence of PPHN within the first 3 days of life were eligible for the study. A matched control group of 27 patients was chosen according to gestational age, date of birth, and gender. Data collection included the need for respiratory support, use of nitric oxide oxygen supplementation, duration of rupture of membranes, blood culture, blood count, and C-reactive protein levels at birth and 12 h. Maternal clinical and laboratory data suggesting clinical chorioamnionitis Placentas of both groups were examined. Differences between groups were analyzed using two-tail t test, Kolmogorov–Smirnov test, Chi-square test. No statistically differences were found in all parameters compared between groups, except for a higher number of patients in the PPHN group who were treated by oxygen supplementation. An association was not found between the incidence of HCA and echocardiographic PPHN in preterm infants in the first 3 days of life.


Preterm newborn Pulmonary hypertension Histologic chorioamnionitis 


Compliance with Ethical Standards

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • N. Katz
    • 1
    • 2
    • 5
  • Y. Bar-Or
    • 3
  • A. Raucher-Sterrnfeld
    • 4
  • A. Tamir
    • 4
  • D. Kohelet
    • 1
    • 2
  1. 1.Neonatal Intensive Care UnitWolfson Medical CenterHolonIsrael
  2. 2.Sackler School of MedicineTel Aviv UniversityTel AvivIsrael
  3. 3.Pediatric DepartmentWolfson Medical CenterHolonIsrael
  4. 4.Pediatric Cardiology UnitWolfson Medical CenterHolonIsrael
  5. 5.Department of NeonatologyWolfson Medical CenterHolonIsrael

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