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Preserved Cardiac Blood Supply–Workload Balance in Pediatric Patients After Aortic Arch Repair

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Abstract

One of the most important problems in patients with aortic coarctation after aortic arch repair is future cardiovascular disease. We have previously reported that the enhancement of aortic pressure wave reflection in patients could be one of the causes of future cardiovascular diseases, because it results in an increase of the left ventricular workload and is disadvantageous for coronary circulation. Seventeen patients who had undergone aortic arch repair without pressure gradient in their aortic arch were enrolled. An ascending aortic pressure waveform was recorded by a pressure-sensor-mounted catheter, and a subendocardial viability ratio, which measures cardiac blood supply–workload balance, was calculated. The values were compared with those in age-matched controls. The patients’ mean age was 6.8 ± 2.8 years. The mean ascending aortic systolic pressure was higher (100.4 ± 12.9 vs. 90.2 ± 8.9 mmHg, p = 0.0011) and the pulse pressure was wider (38.1 ± 7.1 vs. 32.5 ± 5.4 mmHg, p = 0.0072) in patients than in control subjects. There was no difference in the mean subendocardial viability ratio (1.01 ± 0.25 vs. 1.01 ± 0.24, ns), while the mean tension time index (27.4 ± 5.6 vs. 23.0 ± 3.3, p = 0.0001) and diastolic pressure time index (28.4 ± 11.1 vs. 23.6 ± 8.0, p = 0.0082) were higher in patients than in controls. The cardiac blood supply–workload balance was preserved in patients after aortic arch repair, despite an increase in their cardiac workload.

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Acknowledgement

We thank Ashraf Malhas, PhD, from Edanz Group for editing a draft of this manuscript.

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Authors and Affiliations

  1. Department of Cardiology, Chiba Children’s Hospital, 579-1 Heta-cho, Midori-ku, Chiba, 266-0007, Japan

    Tomoaki Murakami

  2. Department of Pediatrics, Hokkaido University Hospital, Sapporo, Japan

    Atsuhito Takeda

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  1. Tomoaki Murakami
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  2. Atsuhito Takeda
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Correspondence to Tomoaki Murakami.

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Murakami, T., Takeda, A. Preserved Cardiac Blood Supply–Workload Balance in Pediatric Patients After Aortic Arch Repair. Pediatr Cardiol 39, 294–298 (2018). https://doi.org/10.1007/s00246-017-1754-y

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  • DOI: https://doi.org/10.1007/s00246-017-1754-y

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