Pediatric Cardiology

, Volume 38, Issue 8, pp 1639–1644 | Cite as

Serum Resistin Negatively Correlates with Clinical Severity of Postural Tachycardia Syndrome in Children

  • Wei Bai
  • Zhenhui Han
  • Siyao Chen
  • Hongxia Li
  • Jingyuan Song
  • Jianguang Qi
  • Ying Liao
  • Chaoshu Tang
  • Ping Liu
  • Yuli Wang
  • Hongfang Jin
  • Junbao Du
Original Article

Abstract

This study was designed to analyse the serum resistin level in children with postural tachycardia syndrome (POTS) and its clinical significance. Twenty-one children with POTS and 31 healthy children as controls participated in the study. Clinical characteristics, heart rate and blood pressure in the supine and upright positions were monitored and collected during an upright test, and the symptom scoring of POTS patients was recorded. The serum resistin levels of patients in both groups were determined by enzyme-linked immunosorbent assay. The change in serum resistin levels in the POTS group before and after standing, as well as its correlation with symptom scores and change in heart rate after standing, was analysed. Compared with the control group, the serum resistin levels in the POTS group were significantly increased (P < 0.01). The serum resistin levels in the POTS group before and after standing did not differ (P > 0.05). There was a negative correlation between the serum resistin levels and a change in heart rate from the supine to upright position (correlation coefficient = −0.615, P < 0.01). Moreover, serum resistin levels were negatively correlated with symptom scores (correlation coefficient = −0.493, P < 0.05). Serum resistin levels in children with POTS were significantly higher than those in healthy children and negatively correlated with a change in heart rate from the supine to upright position and symptom scores. These results suggest a protective role of increased resistin in the pathogenesis of POTS.

Keywords

Postural tachycardia syndrome (POTS) Resistin Children 

Notes

Compliance with Ethical Standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all participants in this study in the form of written consent from parents and written assent from children.

Supplementary material

246_2017_1708_MOESM1_ESM.pdf (197 kb)
Supplementary material 1 (PDF 196 kb)

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Wei Bai
    • 1
  • Zhenhui Han
    • 2
  • Siyao Chen
    • 3
  • Hongxia Li
    • 1
  • Jingyuan Song
    • 1
  • Jianguang Qi
    • 1
  • Ying Liao
    • 1
  • Chaoshu Tang
    • 4
    • 5
  • Ping Liu
    • 1
  • Yuli Wang
    • 1
  • Hongfang Jin
    • 1
  • Junbao Du
    • 1
  1. 1.Department of PediatricsPeking University First HospitalBeijingPeople’s Republic of China
  2. 2.Department of Medical and Educational AdministrationChildren’s Hospital of KaifengKaifengPeople’s Republic of China
  3. 3.Department of the Intensive Care Unit of Cardiac Surgery, Guangdong Cardiovascular InstituteGuangdong General Hospital and Guangdong Academy of Medical SciencesGuangzhouPeople’s Republic of China
  4. 4.Department of Physiology and PathophysiologyPeking University Health Science CenterBeijingPeople’s Republic of China
  5. 5.Key Laboratory of Molecular CardiologyMinistry of EducationBeijingPeople’s Republic of China

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