Pediatric Cardiology

, Volume 38, Issue 7, pp 1505–1514 | Cite as

Hemoglobin Level at Stage 1 Discharge has No Impact on Inter-stage Growth and Stability in Single Ventricle Infants

  • Claudia Delgado-Corcoran
  • Deborah U. Frank
  • Stephanie Bodily
  • Chong Zhang
  • Katherine H. Wolpert
  • Kathryn Lucas
  • Theodore J. Pysher
  • Angela P. Presson
  • Susan L. Bratton
Original Article


Hemoglobin levels (Hgb) of infants with a single ventricle (SV) are traditionally maintained high to maximize oxygen-carrying capacity during stage 1 palliation (S1P), stage 2 palliation (S2P), and between stages (IS). A single-center observational cohort study was performed to determine if red blood cell transfusion during the convalescent phase of the S1P (late S1P transfusion) to achieve higher Hgb is associated with benefits during the IS including improved growth and decreased acute medical events. 137 infants <1 year with SV with SIP undergoing care from January 2008 to June 2015 were retrospectively evaluated. 78 (57%) infants received a late S1P transfusion. Median Hgb at S1P discharge was 15.9 g/dL (IQR 14.7–17.1) and median Hgb S2P at admission was 15.3 g/dL (IQR 14–16.3). Median daily weight gain was 22 g/day during IS (IQR 17–26) and median daily length gain was 0.09 cm (IQR 0.06–0.11). Hgb at SIP discharge was not associated with IS growth or fewer IS acute events. However, late S1P transfusions were associated with illness severity at S1P and more complicated S1P care. Our data suggest that SV infants after S1P, who are steadily recovering, do not benefit from late transfusion to raise their hemoglobin level at discharge.


Hemoglobin levels Stage 1 and 2 palliation Single ventricle physiology Inter-stage period Weight and length gain Inter-stage acute event 


Compliance with Ethical Standards

Conflict of interest

The authors have no conflicts of interest to disclose.


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Claudia Delgado-Corcoran
    • 1
  • Deborah U. Frank
    • 2
  • Stephanie Bodily
    • 3
  • Chong Zhang
    • 4
  • Katherine H. Wolpert
    • 1
  • Kathryn Lucas
    • 3
  • Theodore J. Pysher
    • 5
  • Angela P. Presson
    • 4
  • Susan L. Bratton
    • 1
  1. 1.Department of Pediatrics, Division of Pediatric Critical Care Medicine, School of MedicineUniversity of UtahSalt Lake CityUSA
  2. 2.Department of Pediatrics, Division of Pediatric Critical Care Medicine, School of MedicineUniversity of VirginiaCharlottesvilleUSA
  3. 3.Primary Children’s Hospital, Intermountain Health CareSalt Lake CityUSA
  4. 4.Department of Internal Medicine, Division of Epidemiology, School of MedicineUniversity of UtahSalt Lake CityUSA
  5. 5.Department of Pathology, Division of Pediatric Pathology, School of MedicineUniversity of UtahSalt Lake CityUSA

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