Pediatric Cardiology

, Volume 38, Issue 7, pp 1493–1504 | Cite as

Comparison of Echocardiographic Diagnostic Criteria of Left Ventricular Noncompaction in a Pediatric Population

  • Anna Joong
  • Denise A. Hayes
  • Brett R. Anderson
  • Warren A. Zuckerman
  • Sheila J. Carroll
  • Wyman W. Lai
Original Article

Abstract

Background

There is controversy regarding the best echocardiographic diagnostic criteria for left ventricular noncompaction (LVNC). We assessed the diagnostic utility and reproducibility of the previously proposed echocardiographic diagnostic criteria in a pediatric population using a segmental approach.

Methods

Echocardiograms were matched for patients with and without a clinical diagnosis of LVNC. Blinded reviews of echocardiograms measured (1) depths of intertrabecular recesses (X/Y), (2) noncompaction-to-compaction ratio (NC/C), and (3) number of trabeculations, using a segmental approach. Measurements were analyzed for area under the receiver operating characteristic curves (AUC), sensitivity, and specificity.

Results

There were 30 echocardiograms in the initial cohort (15 LVNC cases, 15 controls). Median age was 1.7 years (IQR 0.2–6.9 years) and systolic function was decreased in 40%. Comparison of diagnostic criteria demonstrated the best interrater agreement and AUC with an X/Y ratio measured in end-diastole in the parasternal short axis in the apical anterolateral segment (κ 0.72, CI 0.43–1.00, p value <0.001), yielding 100% sensitivity and 70–86% specificity, among readers. The least predictive and reproducible method was the NC/C ratio. A validation cohort confirmed the superiority of the X/Y ratio, although the interrater agreement and AUC decreased.

Conclusion

Measurements according to existing LVNC diagnostic criteria vary by echocardiographic view and segment. Modification of the Chin et al. criteria (Circulation 82:507–513, 1990) using an X/Y ratio <0.5 had the greatest interrater reliability and predictive validity when measured in end-diastole in the parasternal short axis in the apical anterolateral segment. The NC/C ratio had the lowest reliability and predictive validity.

Keywords

Left ventricular noncompaction Echocardiography Cardiomyopathy Segment model Pediatrics 

Notes

Acknowledgements

The authors thank Dr. Codruta Chiuzan from the Department of Biostatistics, Columbia University Mailman School of Public Health for her guidance in planning the statistical analysis of this study.

Funding

Funding sources and possible conflicts: Dr. Brett Anderson receives salary support from the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant No. KL2 TR000081. This publication was also supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant No. UL1 TR000040. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Compliance with Ethical Standards

Conflict of interest

The authors have no other conflicts to disclose.

Ethical Approval

For this type of retrospective study, formal consent is not required.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Division of Pediatric CardiologyNewYork-Presbyterian/Morgan Stanley Children’s Hospital, Columbia University Medical CenterNew YorkUSA
  2. 2.Division of Pediatric CardiologyNewYork-Presbyterian/Phyllis and David Komansky Center for Children’s Health, Weill Cornell MedicineNew YorkUSA
  3. 3.Division of Pediatric CardiologySteven and Alexandra Cohen Children’s Medical Center at Northwell HealthNew Hyde ParkUSA
  4. 4.Division of Pediatric CardiologyChildren’s Hospital of Orange CountyOrangeUSA

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