Pediatric Cardiology

, Volume 38, Issue 7, pp 1515–1518 | Cite as

Chronic Low Dose Prostaglandin and Neonatal Heart Block

  • Safwat A. Aly
  • Sawsan M. Awad
  • Ra-id Abdulla
  • Suhaib Kazmouz
  • Hoang H. Nguyen
Case Report


Long-term prostaglandin use is commonly associated with side effects such as cortical proliferation of the bones, hypertrophic pyloric stenosis, and soft tissue swelling of the extremities. We report a neonate with critical coarctation of the aorta, who developed second and third degree atrioventricular blocks associated with prolonged prostaglandin E1 (PGE1) infusion. Interestingly, these conduction blocks only occurred at low PGE1 dose. The rhythm disturbances resolved promptly with the discontinuation of PGE1 following surgical repair.


Heart Block Prostaglandin PGE1 


Compliance with Ethical Standards

Conflict of interest

All the authors declare that they have no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Safwat A. Aly
    • 1
  • Sawsan M. Awad
    • 1
  • Ra-id Abdulla
    • 1
  • Suhaib Kazmouz
    • 1
  • Hoang H. Nguyen
    • 1
  1. 1.Department of Pediatrics, Division of CardiologyRush University Medical CollegeChicagoUSA

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