Myocardial Layers Specific Strain Analysis for the Acute Phase of Infant Kawasaki Disease
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Recently, the prevalence of infant Kawasaki disease (KD) has increased. However, the myocardial functional analysis of infant KD can be difficult and rarely reported. The purpose of this study was to investigate layer specific myocardial strain analysis for better assessment of the acute period in infant KD. The study retrospectively reviewed the echocardiographic data of 25 infant patients with KD at the acute phase. With advanced imaging, pulsed tissue Doppler velocity data, myocardial strain with three layers specific analysis was performed. Then the data were compared with 25 age-matched healthy control infants. The measures of longitudinal strain and radial strain were decreased in infant KD compared to healthy controls. The circumferential strain was significantly decreased in infant KD at all three myocardial layers, especially in the endocardial layer (KD: −20.5 ± 6.4 % vs. control: −25.6 ± 7.6 %, endocardium, p = 0.00001; −14.6 ± 4.4 % vs. −18.1 ± 4.0 %; middle myocardium, p = 0.01; −9.7 ± 3.3 % vs. −11.4 ± 3.8 %; epicardium, p = 0.04). The acute phase of infant KD demonstrated decreased myocardial strain measurement. Circumferential strain was the lowest in the endocardial layer. Further continuous long-term follow up for myocardial assessment should be recommended even after recovery with appropriate treatment.
KeywordsLayer specific myocardial strain Infant Kawasaki disease
This research received no grant from any funding agency in the public, commercial or not-for-profit sectors.
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Conflict of interest
The authors declare that there is no conflict of interest.
- 7.McCandless RT, Minich LL, Wilkinson SE, McFadden ML, Tani LY, Menon SC (2013) Myocardial strain and strain rate in Kawasaki disease. Eur Heart J 14:1061–1068Google Scholar
- 9.Dahifar H, Ghorbani A (2005) Atypical Kawasaki disease in two infants younger than 6 months. J Res Med Sci 10(4):239–243Google Scholar
- 10.Freeman AF, Shulman ST (2006) Kawasaki disease: summary of the American Heart Association Guidelines. Am Fam Phys 74:1141–1148Google Scholar
- 12.Tseng CF, Fu YC, Fu LS, Hwang B, Chi CS (2001) Clinical spectrum of Kawasaki disease in infants. Chin Med J 64:168–173Google Scholar
- 13.Liu HC, Lo CW, Hwang B, Lee PC (2012) Clinical manifestations vary with different age spectrums in infants with Kawasaki disease. Sci World J 15:1–6Google Scholar
- 33.Hiraishi S, Yashiro K, Oguchi K, Kusano S, Ishii K, Nakazawa K (1981) Clinical course of cardiovascular involvement in the mucocutaneous lymph node syndrome. Relation between clinical signs of carditis and development of coronary arterial aneurysm. Am J Cardiol 47(2):323–330CrossRefPubMedGoogle Scholar
- 36.Henry WL, Ware J, Gardin JM, Hepner SI, McKay J, Weiner M (1987) Echocardiographic measurements in normal subjects: Growth-related changes that occur between infancy and early adulthood. Circulation 7:278–285Google Scholar
- 37.Printz BF, Sleeper LA, Newburger JW, Minich LL, Bradley T, Cohen MS, Frank D, Li JS, Margossian R, Shirali G, Takahashi M, Colan SD (2011) Noncoronary cardiac abnormalities are associated with coronary artery dilation and with laboratory inflammatory markers in acute Kawasaki disease. J Am Coll Cardiol 57:86–92CrossRefPubMedPubMedCentralGoogle Scholar