Pediatric Cardiology

, Volume 37, Issue 2, pp 225–231 | Cite as

Circulating Progenitor Cells and Childhood Cardiovascular Disease

  • Eric J. KortEmail author
  • Lacey Croskey
  • Taryn Scibienski
  • Surender Rajasekaran
  • Stefan Jovinge
Review Article


Circulating progenitor cells have been extensively studied in the context of heart disease in adults. In these patients, they have been demonstrated to be markers of myocardial injury and recovery as well as potential therapeutic agents. However, studies in children are much more limited. Here we review current knowledge pertaining to circulating progenitor cells in the context of childhood cardiovascular disease. Priorities for further research are also highlighted.


Congenital heart disease Stem cells Cardiopulmonary bypass Progenitor cells 



This work was supported by the generosity of the Richard and Helen DeVos Foundation.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.DeVos Cardiovascular Research Program of Spectrum Health and Van Andel Research InstituteGrand RapidsUSA
  2. 2.Michigan State University, College of Human MedicineGrand RapidsUSA
  3. 3.Helen DeVos Children’s HospitalGrand RapidsUSA
  4. 4.Cardiovascular InstituteStanford UniversityPalo AltoUSA

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