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Inflammation Aggravates Heterogeneity of Ventricular Repolarization in Children With Kawasaki Disease

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Abstract

Kawasaki disease complicates with myocarditis and vasculitis. Even if myocarditis is asymptomatic, heterogeneity of ventricular repolarization may be increased in the acute phase. We evaluated whether the change in repolarization characteristics can be used as a predictor for myocarditis and coronary lesions. Enrolled 34 children who were treated with intravenous immunoglobulin therapy. There were no sequelae in the recovery phase in any subjects, including those who had transient coronary artery lesion. QT and the interval from the Tpeak to Tend (Tp-e) were determined. The Tp-e/QT ratios were compared between the acute and recovery phases and correlations with CRP level and body temperature were evaluated. A retrospective evaluation of Tp-e/QT as predictors of coronary dilation was also performed. Tp-e/QT in the acute phase correlated positively with body temperature and CRP level. In a comparison of patients with and without transient coronary artery lesion, Tp-e/QT was significantly higher in those with dilation. In conclusion, Tp-e/QT was strongly related to transient coronary dilation, in comparison with inflammatory indicators including fever and CRP level.

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Authors and Affiliations

  1. Department of Pediatrics, Fujita Health University, Toyoake, Japan

    Masayuki Fujino, Tadayoshi Hata, Hidetoshi Uchida, Yoshihiko Eryu, Hiroko Boda, Masafumi Miyata & Tetsushi Yoshikawa

  2. Graduate School of Health Sciences, Fujita Health University, Toyoake, Japan

    Tadayoshi Hata, Marina Kuriki & Kayo Horio

Authors
  1. Masayuki Fujino
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  2. Tadayoshi Hata
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  3. Marina Kuriki
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  4. Kayo Horio
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  5. Hidetoshi Uchida
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  6. Yoshihiko Eryu
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  7. Hiroko Boda
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  8. Masafumi Miyata
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  9. Tetsushi Yoshikawa
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Correspondence to Masayuki Fujino.

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Fujino, M., Hata, T., Kuriki, M. et al. Inflammation Aggravates Heterogeneity of Ventricular Repolarization in Children With Kawasaki Disease. Pediatr Cardiol 35, 1268–1272 (2014). https://doi.org/10.1007/s00246-014-0926-2

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  • DOI: https://doi.org/10.1007/s00246-014-0926-2

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