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The Quantitative and Qualitative Responses of Platelets in Pediatric Patients Undergoing Cardiopulmonary Bypass Surgery

Pediatric Cardiology volume 33, pages 55–59 (2012)Cite this article

Abstract

This prospective, single-center study aimed to evaluate the platelet response during cardiopulmonary bypass (CPB) surgery in a large cohort of children up to 6 years of age. Blood samples were drawn at four time points: after induction of anesthesia, after initiation of the CPB, before protamine, and immediately after chest closure. The study recruited 60 children requiring CPB for surgical repair of congenital heart defects. The platelet count decreased throughout CPB surgery, but during the same period, platelet activity increased. The more pronounced decrease in platelet count observed in children younger than 1 year compared with that of children 1 to 6 years of age was not associated with an age-specific change in platelet activity. The overall increase in platelet function observed in this study could provide a mechanism that compensates for the decrease in platelet count. This study provides a new foundation for future studies investigating requirements of platelet supplementation in the setting of pediatric CPB surgery.

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Acknowledgments

The authors acknowledge the assistance of the cardiothoracic surgical unit, particularly that of Martin Bennett. Internal funding was provided by the Haematology Research Group.

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Affiliations

  1. Murdoch Childrens Research Institute, Flemington Road, Parkville, VIC, 3052, Australia

    Vera Ignjatovic, Robyn Summerhayes, Fiona Newall & Paul Monagle

  2. Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia

    Vera Ignjatovic, Robyn Summerhayes, Fiona Newall, Andrew Cochrane & Paul Monagle

  3. Department of Nursing, The University of Melbourne, Melbourne, VIC, Australia

    Fiona Newall

  4. Department of Clinical Haematology, Royal Children’s Hospital, Melbourne, VIC, Australia

    Jenny Than, Fiona Newall & Paul Monagle

  5. Department of Cardiac Surgery, Royal Children’s Hospital, Melbourne, VIC, Australia

    Steve Horton

  6. Department of Cardiothoracic Surgery, Monash Medical Centre, Melbourne, Australia

    Andrew Cochrane

Authors
  1. Vera Ignjatovic
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  2. Jenny Than
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  3. Robyn Summerhayes
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  4. Fiona Newall
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  5. Steve Horton
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  6. Andrew Cochrane
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  7. Paul Monagle
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Correspondence to Vera Ignjatovic.

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Ignjatovic, V., Than, J., Summerhayes, R. et al. The Quantitative and Qualitative Responses of Platelets in Pediatric Patients Undergoing Cardiopulmonary Bypass Surgery. Pediatr Cardiol 33, 55–59 (2012). https://doi.org/10.1007/s00246-011-0079-5

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  • DOI: https://doi.org/10.1007/s00246-011-0079-5

Keywords

  • Beta-thromboglobulin
  • Cardiopulmonary bypass
  • Children
  • Platelet activation