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Secondary Residual Shunt After Atrial Septal Defect Closure With an Amplatzer Occluder: Surgical Removal and Evaluation of Device Biocompatibility After 7 Years

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Abstract

Interventional occluder implantation has become the preferred mode of treatment in children with clinically significant atrial septal defect (ASD). The continuous increase in the number of patients treated calls for long-term data on device integrity and biocompatibility. We report a child who underwent successful interventional ASD closure at age 5 years. Secondary residual shunt occurred after 3 years of follow-up, and surgical ASD closure became necessary at age 12 years. The Amplatzer occluder device, which was removed after 7 years in vivo, showed no signs of mechanical failure, corrosion, or clinically relevant immunological response at the device–tissue interface.

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Authors and Affiliations

  1. Department of Pediatric Cardiology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, People’s Republic of China

    Weihua Zhu & Henning Neubauer

  2. Department of Pediatric Radiology, Institute of Radiology, University Hospital Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany

    Henning Neubauer

Authors
  1. Weihua Zhu
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  2. Henning Neubauer
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Correspondence to Henning Neubauer.

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Movie clip 1. (A and B) Transthoracic echocardiographic follow-up examination from 2005. A trans-septal flow signal was detected next to the inferior margin of the Amplatzer occluder for the first time after 3 years of follow-up as demonstrated from two different angles

Movie clip 1. (A and B) Transthoracic echocardiographic follow-up examination from 2005. A trans-septal flow signal was detected next to the inferior margin of the Amplatzer occluder for the first time after 3 years of follow-up as demonstrated from two different angles

Movie clip 2. Transthoracic echocardiographic follow-up from 2008. Progression in size of the secondary ASD was documented on follow-up examinations between 2005 and 2008. The secondary ASD reached 10 mm in diameter by 2009, with the Amplatzer occluder still in situ, and eventually required surgical closure

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Zhu, W., Neubauer, H. Secondary Residual Shunt After Atrial Septal Defect Closure With an Amplatzer Occluder: Surgical Removal and Evaluation of Device Biocompatibility After 7 Years. Pediatr Cardiol 31, 1107–1110 (2010). https://doi.org/10.1007/s00246-010-9757-y

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  • DOI: https://doi.org/10.1007/s00246-010-9757-y

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