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Could Lower Bone Turnover be a Cause of Chest Pain During Childhood?

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Abstract

Chest pain, a frequent complaint during childhood, rarely originates from a cardiac pathology. Although it usually is idiopathic, it also could be associated with psychogenic, musculoskeletal, respiratory, and digestive disorders. This study aimed to investigate a possible relation between bone mineral density and chest pain in children. Bone mineral density and bone metabolism parameters were measured for 50 children with chest pain, and the findings were compared with those for 40 age- and sex-matched healthy children. Most of the cases (64%) were in the idiopathic group, and musculoskeletal chest pain was the second most frequent complaint (12%). Although bone mineral densities and osteocalcin levels did not differ significantly between the whole chest pain group and the control group, both were found to be lower in the musculoskeletal chest pain group than in other groups and the control group (p < 0.05). Musculoskeletal chest pain may be related to reduced bone mineral metabolism, and monitoring of risk factors is of particular importance.

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References

  • Bachard KI (2000) Making an impact on pediatric bone health. J Pediatr 136:137–139

    Article  Google Scholar 

  • Bonura F (2009) Prevention, screening, and management of osteoporosis: an overview of the current strategies. Postgrad Med 121:5–17

    Article  PubMed  Google Scholar 

  • Cashman KD, Hill TR, Cotter AA et al (2008) Low vitamin D status adversely affects bone health parameters in adolescents. Am J Clin Nutr 87:1039–1044

    CAS  PubMed  Google Scholar 

  • Cohran VC, Griffiths M, Heubi JE (2008) Bone mineral density in children exposed to chronic glucocorticoid therapy. Clin Pediatr 47:469–475

    Article  Google Scholar 

  • Danduran MJ, Earing MG, Sheridan DC et al (2008) Chest pain: characteristics of children/adolescents. Pediatr Cardiol 29:775–781

    Article  PubMed  Google Scholar 

  • Diamond FB, Bercu BB (2004) Normative laboratory results. In: Pescovitz OH, Eugster EA (eds) Pediatric endocrinology: mechanisms, manifestations and management 2004. Lippincott Williams and Wilkins, Philadelphia, p 817

    Google Scholar 

  • Feinstein RA, Daniel WA (1986) Chronic chest pain in children and adolescent. Pediatr Ann 15:685–689

    CAS  PubMed  Google Scholar 

  • Gokhale J, Selbst SM (2009) Chest pain and chest wall deformity. Pediatr Clin North Am 56:49–65

    Article  PubMed  Google Scholar 

  • Goksen D, Darcan S, Coker M et al (2006) Bone mineral density of healthy Turkish children and adolescents. J Clin Densitom 9:84–90

    Article  PubMed  Google Scholar 

  • Golden NH (2000) Osteoporosis prevention: a pediatric challenge. Arch Pediatr Adolesc Med 254:542–543

    Google Scholar 

  • Gulbahar S, Sahin E, Baydar M et al (2006) Hypermobility syndrome increases the risk for low bone mass. Rheumatology 25:511–514

    Google Scholar 

  • Hahiwara S, Yang SO, Gluer CC et al (1994) Noninvasive bone mineral density measurement in the evaluation of osteoporosis. Rheum Dis Clin North Am 20:651–669

    Google Scholar 

  • Hasanoglu A, Bideci A, Cinaz P et al (2000) Bone mineral density in childhood obesity. J Pediatr Endocrinol Metab 13:307–311

    CAS  PubMed  Google Scholar 

  • Hasanoglu A, Tümer L, Ezgü FS (2004) Vertebra and femur neck bone mineral density values in healthy Turkish children. Turk J Pediatr 46:298–302

    PubMed  Google Scholar 

  • Jensen S (2001) Musculoskeletal causes of chest pain. Aust Fam Physician 30:834–839

    CAS  PubMed  Google Scholar 

  • Jonston CC, Melton LS, Landsay R (1991) Clinical use of bone densitometry. N Eng J Med 324:1105–1109

    Article  Google Scholar 

  • Kosic KC (1999) Chest pain in pediatrics. Pediatr Clin North Am 46:189–203

    Article  Google Scholar 

  • Lin CH, Lin WC, Ho YJ et al (2008) Children with chest pain visiting the emergency department. Pediatr Neonatol 49:26–29

    Article  PubMed  Google Scholar 

  • Lyritis GP, Schoenau E, Skarantavos G (2000) Osteopenic syndromes in the adolescent female. Ann N Y Acad Sci 900:403–408

    Article  CAS  PubMed  Google Scholar 

  • Neyzi O, Gunoz H, Furman A et al (2008) Türk çocuklarında vücut ağırlığı, boy uzunluğu, baş çevresi ve vücut kitle indeksi referans değerleri. Çocuk Sağlığı ve Hastalıkları Dergisi 51:1–14

    Google Scholar 

  • Roberto AM, Terreri MT, Szejnfeld V et al (2002) Bone mineral density in children: association with musculoskeletal pain and/or joint hypermobility. J Pediatr 78:523–528

    Google Scholar 

  • Shaw NJ (2008) Management of osteoporosis in children. Eur J Endocrinol 159:33–39

    Article  Google Scholar 

  • Soyka LA, Fairfield WP, Klibanski A (2000) Hormonal determinants and disorders of peak bone mass in children. J Clin Endocrinol Metab 85:3951–3963

    Article  CAS  PubMed  Google Scholar 

  • Tumer L, Hasanoglu A, Cinaz P et al (1999) Bone mineral density and metabolism in children treated with L-thyroxine. J Pediatr Endocrinol Metab 12:519–523

    CAS  PubMed  Google Scholar 

  • Tunaoglu FS, Olgunturk R, Akcabay S et al (1995) Chest pain in children referred to a cardiology clinic. Pediatr Cardiol 16:69–72

    Article  CAS  PubMed  Google Scholar 

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Acknowledgment

This study was supported in part by grant no. 03.08.02.01 from Kırıkkale University.

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Correspondence to Cihat Sanli.

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Sanli, C., Akalin, N., Kocak, U. et al. Could Lower Bone Turnover be a Cause of Chest Pain During Childhood?. Pediatr Cardiol 31, 991–996 (2010). https://doi.org/10.1007/s00246-010-9743-4

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  • DOI: https://doi.org/10.1007/s00246-010-9743-4

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