Abstract
Chest pain, a frequent complaint during childhood, rarely originates from a cardiac pathology. Although it usually is idiopathic, it also could be associated with psychogenic, musculoskeletal, respiratory, and digestive disorders. This study aimed to investigate a possible relation between bone mineral density and chest pain in children. Bone mineral density and bone metabolism parameters were measured for 50 children with chest pain, and the findings were compared with those for 40 age- and sex-matched healthy children. Most of the cases (64%) were in the idiopathic group, and musculoskeletal chest pain was the second most frequent complaint (12%). Although bone mineral densities and osteocalcin levels did not differ significantly between the whole chest pain group and the control group, both were found to be lower in the musculoskeletal chest pain group than in other groups and the control group (p < 0.05). Musculoskeletal chest pain may be related to reduced bone mineral metabolism, and monitoring of risk factors is of particular importance.
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References
Bachard KI (2000) Making an impact on pediatric bone health. J Pediatr 136:137–139
Bonura F (2009) Prevention, screening, and management of osteoporosis: an overview of the current strategies. Postgrad Med 121:5–17
Cashman KD, Hill TR, Cotter AA et al (2008) Low vitamin D status adversely affects bone health parameters in adolescents. Am J Clin Nutr 87:1039–1044
Cohran VC, Griffiths M, Heubi JE (2008) Bone mineral density in children exposed to chronic glucocorticoid therapy. Clin Pediatr 47:469–475
Danduran MJ, Earing MG, Sheridan DC et al (2008) Chest pain: characteristics of children/adolescents. Pediatr Cardiol 29:775–781
Diamond FB, Bercu BB (2004) Normative laboratory results. In: Pescovitz OH, Eugster EA (eds) Pediatric endocrinology: mechanisms, manifestations and management 2004. Lippincott Williams and Wilkins, Philadelphia, p 817
Feinstein RA, Daniel WA (1986) Chronic chest pain in children and adolescent. Pediatr Ann 15:685–689
Gokhale J, Selbst SM (2009) Chest pain and chest wall deformity. Pediatr Clin North Am 56:49–65
Goksen D, Darcan S, Coker M et al (2006) Bone mineral density of healthy Turkish children and adolescents. J Clin Densitom 9:84–90
Golden NH (2000) Osteoporosis prevention: a pediatric challenge. Arch Pediatr Adolesc Med 254:542–543
Gulbahar S, Sahin E, Baydar M et al (2006) Hypermobility syndrome increases the risk for low bone mass. Rheumatology 25:511–514
Hahiwara S, Yang SO, Gluer CC et al (1994) Noninvasive bone mineral density measurement in the evaluation of osteoporosis. Rheum Dis Clin North Am 20:651–669
Hasanoglu A, Bideci A, Cinaz P et al (2000) Bone mineral density in childhood obesity. J Pediatr Endocrinol Metab 13:307–311
Hasanoglu A, Tümer L, Ezgü FS (2004) Vertebra and femur neck bone mineral density values in healthy Turkish children. Turk J Pediatr 46:298–302
Jensen S (2001) Musculoskeletal causes of chest pain. Aust Fam Physician 30:834–839
Jonston CC, Melton LS, Landsay R (1991) Clinical use of bone densitometry. N Eng J Med 324:1105–1109
Kosic KC (1999) Chest pain in pediatrics. Pediatr Clin North Am 46:189–203
Lin CH, Lin WC, Ho YJ et al (2008) Children with chest pain visiting the emergency department. Pediatr Neonatol 49:26–29
Lyritis GP, Schoenau E, Skarantavos G (2000) Osteopenic syndromes in the adolescent female. Ann N Y Acad Sci 900:403–408
Neyzi O, Gunoz H, Furman A et al (2008) Türk çocuklarında vücut ağırlığı, boy uzunluğu, baş çevresi ve vücut kitle indeksi referans değerleri. Çocuk Sağlığı ve Hastalıkları Dergisi 51:1–14
Roberto AM, Terreri MT, Szejnfeld V et al (2002) Bone mineral density in children: association with musculoskeletal pain and/or joint hypermobility. J Pediatr 78:523–528
Shaw NJ (2008) Management of osteoporosis in children. Eur J Endocrinol 159:33–39
Soyka LA, Fairfield WP, Klibanski A (2000) Hormonal determinants and disorders of peak bone mass in children. J Clin Endocrinol Metab 85:3951–3963
Tumer L, Hasanoglu A, Cinaz P et al (1999) Bone mineral density and metabolism in children treated with L-thyroxine. J Pediatr Endocrinol Metab 12:519–523
Tunaoglu FS, Olgunturk R, Akcabay S et al (1995) Chest pain in children referred to a cardiology clinic. Pediatr Cardiol 16:69–72
Acknowledgment
This study was supported in part by grant no. 03.08.02.01 from Kırıkkale University.
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Sanli, C., Akalin, N., Kocak, U. et al. Could Lower Bone Turnover be a Cause of Chest Pain During Childhood?. Pediatr Cardiol 31, 991–996 (2010). https://doi.org/10.1007/s00246-010-9743-4
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DOI: https://doi.org/10.1007/s00246-010-9743-4