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Tissue–Tissue Interactions During Morphogenesis of the Outflow Tract

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Abstract

The heart forms as a linear heart tube that loops and septates to produce a mature four-chambered structure. The single vessel emerging from the embryonic heart, the truncus arteriosus, divides into the aorta and the pulmonary artery as part of this septation process, and a series of additional morphogenetic events result in the proper alignment and orientation of the cardiac outflow tract. Recent evidence indicates that this process involves the complex interactions of multiple cell types including primary and secondary heart fields, neural crest, pharyngeal mesenchyme, endoderm, and endothelium. Among the many signals that mediate tissue–tissue interactions during the formation of the outflow tract, we have focused on the role of the Notch signaling pathway. Here, we focus on recent advances in our understanding of Notch-mediated regulation of cardiac development with specific attention to the formation of the cardiac outflow tract.

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Acknowledgments

We would like to thank the members of the Epstein laboratory for many helpful discussions. This work was supported by the American Heart Association Physician-Scientist/Post-Doctoral fellowship (AHA0825548D) to R.J., the University of Pennsylvania, Division of Cardiology T-32 and Benjamin & Mary Siddons Measey Foundation to S.R., and NIH P01 HL075215 and funds from the WW Smith Endowed Chair for Cardiovascular Research to J.A.E.

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Authors and Affiliations

  1. Department of Cell and Developmental Biology, Penn Cardiovascular Institute, and the Institute for Regenerative Medicine, University of Pennsylvania, 1154 BRB II, 421 Curie Blvd, Philadelphia, PA, 19104, USA

    Stacey Rentschler, Rajan Jain & Jonathan A. Epstein

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  1. Stacey Rentschler
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  2. Rajan Jain
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  3. Jonathan A. Epstein
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Correspondence to Jonathan A. Epstein.

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Stacey Rentschler and Rajan Jain contributed equally to this work.

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Rentschler, S., Jain, R. & Epstein, J.A. Tissue–Tissue Interactions During Morphogenesis of the Outflow Tract. Pediatr Cardiol 31, 408–413 (2010). https://doi.org/10.1007/s00246-009-9611-2

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  • DOI: https://doi.org/10.1007/s00246-009-9611-2

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