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Oral Ibuprofen and Ductus Arteriosus Closure in Full-Term Neonates: A Prospective Case–Control Study

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Abstract

Management of patent ductus arteriosus (PDA) in full-term neonates remains controversial. We evaluated the effects of oral ibuprofen on PDA closure in 51 full-term neonates. All neonates were >3-days-old and had a gestational age ≥37 weeks. Patients with ductal-dependent congenital heart disease or severe pulmonary artery hypertension (gradient >40 mmHg) were excluded. Patients were randomly assigned to the treatment group (n = 30) or the control group (n = 21). The treated group received ibuprofen suspension (initially 10 mg/kg, then two 5-mg/kg doses 24 h apart), and control neonates received a placebo. Physicians who treated the patients were blinded to group assignment. There was a statistically significant difference in the closure rate of PDA between the treated (73.3%) and control groups (42.9%, P = 0.029). Among neonates with PDA closure, there was a significant difference in the day of closure between the two groups (25.49 and 17.65% on the days 4 and 14 after diagnosis of PDA in treated neonates versus 1.96 and 15.69% in controls, respectively). This study showed the efficacy of oral ibuprofen in achieving earlier closure of PDA in full-term neonates.

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Acknowledgements

The authors thank Mrs. N. Shokrpour at the Center for Development of Clinical Research of Namazee Hospital for assistance and K. Shashok (AuthorAID in the Eastern Mediterranean) for help with the English in the manuscript. This research was supported by the Vice-Chancellory for Research of Shiraz University of Medical Sciences.

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Authors and Affiliations

  1. Department of Pediatrics, Namazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

    Hamid Amoozgar, Mohammad Ghodstehrani & Narjes Pishva

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  1. Hamid Amoozgar
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  2. Mohammad Ghodstehrani
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  3. Narjes Pishva
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Correspondence to Mohammad Ghodstehrani.

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Amoozgar, H., Ghodstehrani, M. & Pishva, N. Oral Ibuprofen and Ductus Arteriosus Closure in Full-Term Neonates: A Prospective Case–Control Study. Pediatr Cardiol 31, 40–43 (2010). https://doi.org/10.1007/s00246-009-9542-y

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  • DOI: https://doi.org/10.1007/s00246-009-9542-y

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