Abstract
We describe two children with previous anthracycline exposure for cancer who presented with acute decompensated left ventricular dysfunction. Both patients had evidence of dilated cardiomyopathy and required mechanical ventilation and inotropic support. Parvovirus B19 was detected by polymerase chain reaction of the blood. After several weeks of ventilation and inotropic support, both patients were weaned from ventilation and managed with oral carvedilol, ACE inhibition, and diuretics. Acute left ventricular decompensation in patients following anthracycline exposure may not be solely attributed to drug exposure, and viral etiologies should be considered.
Similar content being viewed by others
References
Beghetti M, Gervaix A, Haenggeli CA, Berner M, Rimensberger PC (2000) Myocarditis associated with parvovirus B19 infection in two siblings with merosin-deficient congenital muscular dystrophy. Eur J Pediatr 159:135–136
Bowles KR, Gibson J, Wu J, et al. (1999) Genomic organization and chromosomal localization of the human Coxsackie B-adenovirus receptor gene. Hum Genet 105:354–359
Bowles NE, Ni J, Kearney DL, et al. (2003) Detection of viruses in myocardial tissues by polymerase chain reaction: evidence of adenovirus as a common cause of myocarditis in children and adults. J Am Coll Cardiol 42:466–472
Bu’Lock FA, Mott MG, Oakhill A, Martin RP (1996) Early identification of anthracycline cardiomyopathy: possibilities and implications. Arch Dis Child 75:416–422
Francalanci P, Chance JL, Vatta M, et al. (2004) Cardiotropic viruses in the myocardium of children with end-stage heart disease. J Heart Lung Transplant 23:1046–1052
Lipshultz SE, Rifai N, Dalton VM, et al. (2004) The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia. N Engl J Med 351:145–153
Munro K, Croxson MC, Thomas S, Wilson NJ (2003) Three cases of myocarditis in childhood associated with human parvovirus (B19). Pediatr Cardiol 24:473–475
Nigro G, Bastianon V, Colloridi V, et al. (2000) Human parvovirus B19 infection in infancy associated with acute and chronic lymphocytic myocarditis and high cytokine levels: report of 3 cases and review. Clin Infect Dis 31:65–69
Nousiainen T, Vanninen E, Jantunen E, et al. (2001) Anthracycline-induced cardiomyopathy: long-term effects on myocardial cell integrity, cardiac adrenergic innervation and fatty acid uptake. Clin Physiol 21:123–128
Schowengerdt KO, Ni J, Denfield SW, et al. (1997) Association of parvovirus B19 genome in children with myocarditis and cardiac allograft rejection: diagnosis using the polymerase chain reaction. Circulation 96:3549–3554
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
McMahon, C.J., Murchan, H., Prendiville, T. et al. Parvovirus B19 Infection Associated with Dilated Cardiomyopathy in Patients with Previous Anthracycline Exposure. Pediatr Cardiol 28, 394–395 (2007). https://doi.org/10.1007/s00246-006-0147-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00246-006-0147-4