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Use of Dexmedetomidine in Patients with Trisomy 21 After Cardiac Surgery

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Children with trisomy 21 have a high incidence of congenital heart disease that frequently requires surgical repair. These patients often require multiple and higher dosage sedatives during the postoperative period. Dexmedetomidine is an α2-adrenergic receptor agonist that has sedative, analgesic, and anxiolytic properties. We report the successful use of dexmedetomidine in patients with trisomy 21 following surgical repair of congenital heart disease.

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We thank Dr. Timothy S. Yeh and Dr. Joel T. Hardin (Department of Pediatrics, Children’s Hospital of New Jersey) for their critical review of the manuscript.

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Correspondence to M. Kalyanaraman.

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Kalyanaraman, M., Costello, J. & Starr, J. Use of Dexmedetomidine in Patients with Trisomy 21 After Cardiac Surgery. Pediatr Cardiol 28, 396–399 (2007).

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