Skip to main content

Advertisement

SpringerLink
Log in

Cardiovascular Hemodynamics: Relationships with Insulin Resistance in Obese Children

  • Published:
Pediatric Cardiology Aims and scope Submit manuscript

Abstract

We investigated blood pressure (BP), cardiac output (CO), and systemic vascular resistance (SVR) and their relationships with insulin and glucose blood levels in a group of 24 obese children (mean age, 11.9 ± 2.1 years; 19 males). The data were compared to those obtained from a group of 19 healthy controls of the same age (12.4 ± 2.1 years; p = NS; 13 males). BP at rest was measured and all subjects underwent an exercise testing on the treadmill (Bruce Prot.), time of exercise, maximal heart rate, maximum systolic blood pressure, CO, and SVR at rest and at peak exercise were considered. Only in the OC group were an oral glucose tolerance test were performed to calculate insulin sensitivity index (ISI) and echocardiography performed to determine the left ventricular mass (LVM). The relationships between cardiovascular and metabolic parameters were investigated. Student’s t-test and linear regression analysis were used when appropriate. OC had a significant reduction in TE and higher BP, and linear regression analysis showed significant correlations between BP, ISI, and LVM. We speculate that OC need a regular cardiovascular and metabolic screening to prevent the development of early cardiovascular damage.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4

Similar content being viewed by others

References

  • A Benetos F Thomas ME Safar KE Bean L Guize (2001) ArticleTitleShould diastolic and systolic blood pressure be considered for cardiovascular risk evaluation: a study in middle-aged men and women. J Am Coll Cardiol 37 163–168 Occurrence Handle10.1016/S0735-1097(00)01092-5 Occurrence Handle1:STN:280:DC%2BD3M%2FptlyrsA%3D%3D Occurrence Handle11153732

    Article  CAS  PubMed  Google Scholar 

  • G De Simone SR Daniels RB Devereux et al. (1992) ArticleTitleLeft ventricular mass and body size in normotensive children and adults: assessment of allometric relations and impact of overweight. J Am Coll Cardiol 20 1251–1260 Occurrence Handle1401629

    PubMed  Google Scholar 

  • G De Simone RB Devereux SR Daniels et al. (1997) ArticleTitleStroke volume and cardiac output in normotensive children and adults: assessment of relations with body size and impact of overweight. Circulation 95 1837–1843 Occurrence Handle1:STN:280:ByiB287itFM%3D Occurrence Handle9107171

    CAS  PubMed  Google Scholar 

  • MI Harris (1998) ArticleTitleDiabetes in America: epidemiology and scope of the problem. Diabetes Care 21 IssueIDsuppl 3 C11–C14 Occurrence Handle9850480

    PubMed  Google Scholar 

  • A Ilercil RB Devereux MJ Roman et al. (2001) ArticleTitleRelationship of impaired glucose tolerance to left ventricular structure and function: The Strong Heart Study. Am Heart J 141 992–998 Occurrence Handle10.1067/mhj.2001.115302 Occurrence Handle1:STN:280:DC%2BD3Mzhs1Wmsw%3D%3D Occurrence Handle11376315

    Article  CAS  PubMed  Google Scholar 

  • JA Martinez (2000) ArticleTitleObesity in young Europeans: genetic and environmental influences. Eur J Clin Nutr 54 IssueIDsuppl 1 S56–S60 Occurrence Handle10805040

    PubMed  Google Scholar 

  • M Matsuda RA DeFronzo (1999) ArticleTitleInsulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22 1462–1470 Occurrence Handle10480510

    PubMed  Google Scholar 

  • JA Millar AF Lever V Burke (1999) ArticleTitlePulse pressure as a risk factor for cardiovascular events in the MRC mild hypertension trial. J Hypertens 17 1065–1072 Occurrence Handle10.1097/00004872-199917080-00004 Occurrence Handle1:STN:280:DyaK1MzpsVegtA%3D%3D Occurrence Handle10466460

    Article  CAS  PubMed  Google Scholar 

  • GM Reaven (1998) ArticleTitleInsulin resistance and human disease: a short history. J Basic Clin Physiol Pharmacol 9 387–406 Occurrence Handle1:CAS:528:DyaK1MXitVyntL4%3D Occurrence Handle10212844

    CAS  PubMed  Google Scholar 

  • Z Sasson Y Rasooly T Bhesania I Rasooly (1993) ArticleTitleInsuline resistance is an important determinant of left ventricular mass in the obese. Circulation 88 1431–1436 Occurrence Handle1:STN:280:ByuD3cjgtF0%3D Occurrence Handle8403289

    CAS  PubMed  Google Scholar 

  • J Sorof S Daniels (2002) ArticleTitleObesity hypertension in children: a problem of epidemic proportions. Hypertension 40 441–447 Occurrence Handle10.1161/01.HYP.0000032940.33466.12 Occurrence Handle1:CAS:528:DC%2BD38Xntlamsrc%3D Occurrence Handle12364344

    Article  CAS  PubMed  Google Scholar 

  • JM Sorof T Poffenbarger K Franco L Bernard RJ Portman (2002) ArticleTitleIsolated systolic hypertension, obesity and hyperkinetic hemodynamic states in children. J Pediatr 140 643–645 Occurrence Handle10.1067/mpd.2002.125519 Occurrence Handle12072864

    Article  PubMed  Google Scholar 

  • InstitutionalAuthorNameUpdate on the 1987 Second Task Force Report on High Blood Pressure in Children and Adolescents: a working group report from the National High Blood Pressure Education Programme (1996) ArticleTitle. Pediatrics 98 649–658 Occurrence Handle8885941

    PubMed  Google Scholar 

  • P Verdecchia G Reboldi G Schillaci et al. (1999) ArticleTitleCirculating insulin and insulin growth factor-1 are independent determinants of left ventricular mass and geometry in essential hypertension. Circulation 100 1802–1807 Occurrence Handle1:CAS:528:DyaK1MXntl2gsLk%3D Occurrence Handle10534468

    CAS  PubMed  Google Scholar 

  • KF Zwiauer (2000) ArticleTitlePrevention and treatment of overweight and obesity in children and adolescents. Eur J Pediatr 159 IssueIDsuppl 1 S56–S68 Occurrence Handle11011956

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sports Medicine Unit, Pediatrics Department, Bambino Gesù Children’s Hospital, Research Institute, Piazza S. Onofrio, 4, 00165 Rome, Italy

    U. Giordano, A. Turchetta, F. Calzolari & A. Calzolari

  2. Endocrinology Unit, Pediatrics Department, Bambino Gesù Children’s Hospital, Research Institute, Piazza S. Onofrio, 4, 00165 Rome, Italy

    P. Ciampalini & A. Crinò

  3. Cardiology Department, Bambino Gesù Children’s Hospital, Research Institute, Piazza S. Onofrio, 4, 00165 Rome, Italy

    A. Santilli & E. Pompei

  4. Department of Pediatrics, University of Tennessee, Memphis, Tennessee, USA

    B. S. Alpert

Authors
  1. U. Giordano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Ciampalini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Turchetta
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Santilli
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. Calzolari
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Crinò
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. E. Pompei
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. B. S. Alpert
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A. Calzolari
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to U. Giordano.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Giordano, U., Ciampalini, P., Turchetta, A. et al. Cardiovascular Hemodynamics: Relationships with Insulin Resistance in Obese Children. Pediatr Cardiol 24, 548–552 (2003). https://doi.org/10.1007/s00246-003-0368-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00246-003-0368-8

Keywords

Search

Navigation