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Monitoring of Polychlorinated Biphenyls in Human Blood Plasma: Methodological Developments and Influence of Age, Lactation, and Fish Consumption

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Abstract.

Human plasma samples from 50 wives of fishermen have been analyzed with respect to PCBs. The non-ortho-substituted PCB congeners CB-126 and CB-169 were determined by mass spectrometry in negative ion chemical ionization mode, which demonstrated a limit of detection of 30 fg. The recoveries of the internal standards used for determination of ortho-substituted CBs were approximately 95%. Two methods, one gravimetric and the other based on enzymatic determinations of triglycerides, cholesterol and phospholipids, were compared for the determination of total amount of lipids in the plasma samples; the correlation coefficient was 0.82 and the slope 0.98. For practical reasons, enzymatic determinations are recommended for further use. The total, lipid-adjusted concentrations of PCBs in plasma were influenced by age, total lactation time and consumption of fatty fish from the Baltic Sea.

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Received: 16 January 1996/Revised: 28 May 1996

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Grimvall, E., Rylander, L., Nilsson-Ehle, P. et al. Monitoring of Polychlorinated Biphenyls in Human Blood Plasma: Methodological Developments and Influence of Age, Lactation, and Fish Consumption . Arch. Environ. Contam. Toxicol. 32, 329–336 (1997). https://doi.org/10.1007/s002449900193

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  • DOI: https://doi.org/10.1007/s002449900193

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