Skip to main content
SpringerLink
Log in

Effects of CeO2 Nanoparticles on Terrestrial Isopod Porcellio scaber: Comparison of CeO2 Biological Potential with Other Nanoparticles

  • Published:
Archives of Environmental Contamination and Toxicology Aims and scope Submit manuscript

Abstract

Nano-sized cerium dioxide (CeO2) particles are emerging as an environmental issue due to their extensive use in automobile industries as fuel additives. Limited information is available on the potential toxicity of CeO2 nanoparticles (NPs) on terrestrial invertebrates through dietary exposure. In the present study, the toxic effects of CeO2 NPs on the model soil organism Porcellio scaber were evaluated. Nanotoxicity was assessed by monitoring the lipid peroxidation (LP) level and feeding rate after 14-days exposure to food amended with nano CeO2. The exposure concentration of 1000 μg of CeO2 NPs g−1 dry weight food for 14 days significantly increased both the feeding rate and LP. Thus, this exposure dose is considered the lowest observed effect dose. At higher exposure doses of 2000 and 5000 μg of CeO2 NPs g−1 dry weight food, NPs significantly decreased the feeding rate and increased the LP level. Comparative studies showed that CeO2 NPs are more biologically potent than TiO2 NPs, ZnO NPs, CuO NPs, CoFe2O4 NPs, and Ag NPs based on feeding rate using the same model organism and experimental setup. Based on comparative metal oxide NPs toxicities, the present results contribute to the knowledge related to the ecotoxicological effects of CeO2 NPs in terrestrial invertebrates exposed through feeding.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Explore related subjects

Discover the latest articles, news and stories from top researchers in related subjects.

References

  • Arnold MC, Badireddy AR, Wiesner MR, Di Giulio RT, Meyer JN (2013) Cerium oxide nanoparticles are more toxic than equimolar bulk cerium oxide in Caenorhabditis elegans. Arch Environ Contam Toxicol 65:224–233. doi:10.1007/s00244-013-9905-5

    Article  CAS  Google Scholar 

  • Artells E, Issartel J, Auffan M, Borschneck D, Thill A, Tella M, Brousset L, Rose J, Bottero J-Y, Thiéry A (2013) Exposure to cerium dioxide nanoparticles differently affect swimming performance and survival in two daphnid species. PLoS ONE 8:1–11

    Article  Google Scholar 

  • Batley GE, Halliburton B, Kirby JK, Doolette CL, Navarro D, McLaughlin MJ, Veitch C (2013) Characterization and ecological risk assessment of nanoparticulate CeO2 as a diesel fuel catalyst. Environ Toxicol Chem 32:1896–1905

    Article  CAS  Google Scholar 

  • Chen S, Hou Y, Cheng G, Zhang C, Wang S, Zhang J (2013) Cerium oxide nanoparticles protect endothelial cells from apoptosis induced by oxidative stress. Biol Trace Elem Res 154:156–166

    Article  CAS  Google Scholar 

  • Collin B, Oostveen E, Tsyusko OV, Unrine JM (2014) Influence of natural organic matter and surface charge on the toxicity and bioaccumulation of functionalized ceria nanoparticles in Caenorhabditis elegans. Environ Sci Technol 48:1280–1289

    Article  CAS  Google Scholar 

  • Cornelis G, Ryan B, McLaughlin MJ, Kirby JK, Beak D, Chittleborough D (2011) Solubility and batch retention of CeO2 nanoparticles in soils. Environ Sci Technol 45:2777–2782

    Article  CAS  Google Scholar 

  • Drobne D (1997) Terrestrial ispods—a good choice for toxicity testing of pollutants in the terrestrial environment. Environ Toxicol Chem 16:1159–1164

    CAS  Google Scholar 

  • Drobne D, Jemec A, Pipan-Tkalec Z (2009) In vivo screening to determine hazards of nanoparticles: nanosized TiO2. Environ Pollut 157:1157–1164

    Article  CAS  Google Scholar 

  • Felix LC, Ortega VA, Ede JD, Goss GG (2013) Physicochemical characteristics of polymer-coated metal-oxide nanoparticles and their toxicological effects on zebrafish (Danio rerio) development. ASC Environ Sci Technol 47:6589–6596

    CAS  Google Scholar 

  • Gaiser BK, Biswas A, Rosenkranz P, Jepson MA, Lead JR, Stone V, Tyler CR, Fernandes TF (2011) Effects of silver and cerium dioxide micro- and nano-sized particles on Daphnia magna. J Environ Monit 13:1227–1235

    Article  CAS  Google Scholar 

  • Gambardella C, Gallus L, Gatti AM, Faimali M, Carbone S, Antisari LV, Falugi C, Ferrando S (2014) Toxicity and transfer of metal oxide nanoparticles from microalgae to sea urchin larvae. Chem Ecol 30:308–316

    Article  CAS  Google Scholar 

  • García A, Espinosa R, Delgado L, Casals E, González E, Puntes V, Barata C, Font X, Sánchez A (2011) Acute toxicity of cerium oxide, titanium oxide and iron oxide nanoparticles using standardized tests. Desalination 269:136–141

    Article  Google Scholar 

  • Golobič M, Jemec A, Drobne D, Romih T, Kasemets K, Kahru A (2012) Upon exposure to Cu nanoparticles, accumulation of copper in the isopod Porcellio scaber is due to the dissolved Cu ions inside the digestive tract. Environ Sci Technol 46:12112–12119

    Article  Google Scholar 

  • Gottschalk F, Sun TY, Nowack B (2013) Environmental concentrations of engineered nanomaterials: review of modelling and analytical studies. Environ Pollut 181:287–300

    Article  CAS  Google Scholar 

  • Karakoti AS, Monteiro-Riviere NA, Aggarwal R, Davis JP, Narayan RJ, McGinnis J, Seal S (2008) Nanoceria as antioxidant: synthesis and biomedical applications. J Miner Met Mater Soc 60:33–37

    Article  CAS  Google Scholar 

  • Karakoti AS, Munusamy P, Hostetler K, Kodali V, Kuchibhatla S, Orr G, Pounds JG, Teeguarden JG, Thrall BD, Baer DR (2012) Preparation and characterization challenges to understanding environmental and biological impacts of nanoparticles. Surf Interface Anal 44:882–889

    Article  CAS  Google Scholar 

  • Lahive E, Jurkschat K, Shaw BJ, Handy RD, Spurgeon DJ, Svendsen C (2014) Toxicity of cerium oxide nanoparticles to the earthworm Eisenia fetida: subtle effects. Environ Chem 11:268–278

    Article  CAS  Google Scholar 

  • Lee SW, Kim SM, Choi J (2009) Genotoxicity and ecotoxicity assays using the freshwater crustacean Daphnia magna and the larva of the aquatic midge Chironomus riparius to screen the ecological risks of nanoparticle exposure. Environ Toxicol Pharmacol 28:86–91

    Article  CAS  Google Scholar 

  • Lynch I, Weiss C, Valsami-Jones E (2014) A strategy of grouping nanomaterials based on physico-chemical descriptors as a basis for safer-by-design NMs. Nanotoday 9:266–270

    Article  CAS  Google Scholar 

  • Malev O, Sauerborn Klobučar R, Fabbretti E, Trebše P (2012) Comparative toxicity of imidacloprid and its transformation product 6-chloronicotinic acid to non-target aquatic organisms: Microalgae Desmodesmus subspicatus and Gammarus fossarum. Pestic Biochem Physiol 204:178–186

    Article  Google Scholar 

  • Manier N, Bado-Nilles A, Delalain P, Aguerre-Chariol O, Pandard P (2013) Ecotoxicity of non-aged and aged CeO2 nanomaterials towards freshwater microalgae. Environ Pollut 180:63–70

    Article  CAS  Google Scholar 

  • McShane H, Sarrazin M, Whalen JK, Hendershot WH, Sunahara GI (2012) Reproductive and behavioral responses of earthworms exposed to nano-sized titanium dioxide in soil. Environ Toxicol Chem 31:184–193

    Article  CAS  Google Scholar 

  • Novak S, Drobne D, Valant J, Pipan-Tkalec Ž, Pelicon P, Vavpetič P, Grlj N, Falnoga I, Mazej D, Remškar M (2012a) Cell membrane integrity and internalization of ingested TiO2 nanoparticles by digestive gland cells of a terrestrial isopod. Environ Toxicol Chem 31:1083–1090

    Article  CAS  Google Scholar 

  • Novak S, Drobne D, Menard A (2012b) Prolonged feeding of terrestrial isopod (Porcellio scaber, Isopoda, Crustacea) on TiO2 nanoparticles. Absence of toxic effect. Zookeys 273:261–273

    Article  Google Scholar 

  • Novak S, Drobne D, Valant J, Pelicon P (2012c) Internalization of consumed nanoparticles by a model invertebrate organism. J Nanomater 2012:1–8. doi:10.1155/2012/658752

    Article  Google Scholar 

  • Novak S, Drobne D, Golobič M, Zupanc J, Romih T, Gianoncelli A, Kiskinova M, Kaulich B, Pelicon P, Vavpetič P, Jeromel L, Ogrinc N, Makovec D (2013) Cellular internalization of dissolved cobalt ions from ingested CoFe2O4 nanoparticles: in vivo experimental evidence. Environ Sci Technol 47:5400–5408

    Article  CAS  Google Scholar 

  • Organization for Economic Cooperation and Development (OECD) (2013) OECD Environment, Health and Safety Publications, Series on the Safety of Manufactured Nanomaterials, Document No. 37, Current developments in delegations on the safety of the manufactured nanomaterials—tour de table. ENV/JM/MONO(2013)2

  • Park EJ, Choi J, Park YK, Park K (2008) Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells. Toxicology 245:90–100

    Article  CAS  Google Scholar 

  • Pipan-Tkalec Ž, Drobne D, Jemec A, Romih T, Zidar P, Bele M (2010) Zinc bioaccumulation in a terrestrial invertebrate fed a diet treated with particulate ZnO or ZnCl2 solution. Toxicology 269:198–203

    Article  CAS  Google Scholar 

  • Rodea-Palomares I, Boltes K, Fernández-Piñas F, Leganés F, García-Calvo E, Santiago J, Rosal R (2011) Physicochemical characterization and ecotoxicological assessment of CeO2 nanoparticles using two aquatic microorganisms. Toxicol Sci 119:135–145

    Article  CAS  Google Scholar 

  • Roh JY, Park YK, Park K, Choi J (2010) Ecotoxicological investigation of CeO2 and TiO2 nanoparticles on the soil nematode Caenorhabditis elegans using gene expression, growth, fertility, and survival as endpoints. Environ Toxicol Pharmacol 29:167–172

    Article  CAS  Google Scholar 

  • Schlich K, Klawonn T, Terytze K, Hund-Rinke K (2012a) Effects of silver nanoparticles and silver nitrate. Environ Toxicol Chem 32:181–188

    Article  Google Scholar 

  • Schlich K, Terytze K, Hund-Rinke K (2012b) Effect of TiO2 nanoparticles in the earthworm reproduction test. Environ Sci Europe 24:1–10

    Article  Google Scholar 

  • Šećerov B, Andrić Ž, Abazović N, Krsmanović R, Mitrić M, Montone A, Dramićanin M (2008) Combustion synthesis and characterization of CeO2 nanopowder. Acta Chim Slov 55:486–491

    Google Scholar 

  • Shoults-Wilson WA, Reinsch BC, Tsyusko OV, Bertsch PM, Lowry GV, Unrine JM (2011a) Role of particle size and soil type in toxicity of silver nanoparticles to earthworms evidence for avoidance of Ag nanoparticles by earthworms (Eisenia fetida). Soil Sci Soc Am J 75:365–377

    Article  CAS  Google Scholar 

  • Shoults-Wilson WA, Reinsch BC, Tsyusko OV, Bertsch PM, Lowry GV, Unrine JM (2011b) Effect of silver nanoparticle surface coating on bioaccumulation and reproductive toxicity in earthworms (Eisenia fetida). Nanotoxicology 5:432–444

    Article  CAS  Google Scholar 

  • Unrine JM, Tsyusko OV, Hunyadi SE, Judy JD, Bertsch PM (2010a) Effects of particle size on chemical speciation and bioavailability of copper to earthworms (Eisenia fetida) exposed to copper nanoparticles. J Environ Qual 39:1942–1953

    Article  CAS  Google Scholar 

  • Unrine JM, Hunyadi SE, Tsyusko OV, Rao W, Shoults-Wilson WA, Bertsch PM (2010b) Evidence for bioavailability of Au nanoparticles from soil and biodistribution within earthworms (Eisenia fetida). Environ SciTechnol 44:8308–8313

    Article  CAS  Google Scholar 

  • US EPA (2004) Interim registration eligibility decision. Prevention pesticides and toxic substances (7508C). 738-R-04-006. http://envirocancer.cornell.edu/turf/pdf/diazinon_ired.pdf. Accessed 2 May 2015

  • Valant J, Drobne D, Novak S (2012) Effect of ingested titanium dioxide nanoparticles on the digestive gland cell membrane of terrestrial isopods. Chemosphere 87:19–25

    Article  CAS  Google Scholar 

  • Van Hoecke K, Quik JTK, Mankiewicz-Boczek J, De Schamphelaere KC, Elsaesser A, Van der Meeren P (2009) Fate and effects of CeO2 nanoparticles in aquatic ecotoxicity tests. Environ Sci Technol 43:4537–4546

    Article  Google Scholar 

  • Xia T, Kovochich M, Liong M, Madler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE (2008) Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2:2121–2134

    Article  CAS  Google Scholar 

  • Xia J, Zhao HZ, Lu GH (2013) Effects of selected metal oxide nanoparticles on multiple biomarkers in Carassius auratus. Biomed Environ Sci 26:742–749

    CAS  Google Scholar 

  • Xu C, Qu X (2014) Cerium oxide nanoparticle: a remarkably versatile rare earth nanomaterial for biological applications. NPG Asia Mater 6:1–16

    Article  Google Scholar 

  • Zhang H, He X, Zhang Z, Zhang P, Li Y, Ma Y, Kuang Y, Zhao Y, Chai Z (2011) Nano-CeO2 exhibits adverse effects at environmental relevant concentrations. Environ Sci Technol 45:3725–3730

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors thank M. Hočevar for SEM images of nanoparticles taken at the Institute of Metals and Technology in Ljubljana, Slovenia. The present work was funded via the European Commission 7th Framework Programme project “NanoMILE” (contract no. NMP4-LA-2013-310451). A part of work was conducted at Center of excellence in Nanoscience and Nanotechnology, Ljubljana, Slovenia.

Author information

Authors and Affiliations

  1. University of Nova Gorica, 5000, Nova Gorica, Slovenia

    Olga Malev, Polonca Trebše & Małgorzata Piecha

  2. Department of Biology, Biotechnical Faculty, University of Ljubljana, Večna pot 111, 1000, Ljubljana, Slovenia

    Sara Novak & Damjana Drobne

  3. National Institute of Chemistry, 1001, Ljubljana, Slovenia

    Bojan Budič

  4. Institute of Nuclear Sciences - Vinča, 11000, Beograd, Serbia

    Miroslav D. Dramićanin

Authors
  1. Olga Malev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Polonca Trebše
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Małgorzata Piecha
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sara Novak
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Bojan Budič
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Miroslav D. Dramićanin
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Damjana Drobne
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sara Novak.

Electronic Supplementary Material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOC 914 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Malev, O., Trebše, P., Piecha, M. et al. Effects of CeO2 Nanoparticles on Terrestrial Isopod Porcellio scaber: Comparison of CeO2 Biological Potential with Other Nanoparticles. Arch Environ Contam Toxicol 72, 303–311 (2017). https://doi.org/10.1007/s00244-017-0363-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00244-017-0363-3

Keywords

Search

Navigation