Effects of CeO2 Nanoparticles on Terrestrial Isopod Porcellio scaber: Comparison of CeO2 Biological Potential with Other Nanoparticles

  • Olga Malev
  • Polonca Trebše
  • Małgorzata Piecha
  • Sara Novak
  • Bojan Budič
  • Miroslav D. Dramićanin
  • Damjana Drobne


Nano-sized cerium dioxide (CeO2) particles are emerging as an environmental issue due to their extensive use in automobile industries as fuel additives. Limited information is available on the potential toxicity of CeO2 nanoparticles (NPs) on terrestrial invertebrates through dietary exposure. In the present study, the toxic effects of CeO2 NPs on the model soil organism Porcellio scaber were evaluated. Nanotoxicity was assessed by monitoring the lipid peroxidation (LP) level and feeding rate after 14-days exposure to food amended with nano CeO2. The exposure concentration of 1000 μg of CeO2 NPs g−1 dry weight food for 14 days significantly increased both the feeding rate and LP. Thus, this exposure dose is considered the lowest observed effect dose. At higher exposure doses of 2000 and 5000 μg of CeO2 NPs g−1 dry weight food, NPs significantly decreased the feeding rate and increased the LP level. Comparative studies showed that CeO2 NPs are more biologically potent than TiO2 NPs, ZnO NPs, CuO NPs, CoFe2O4 NPs, and Ag NPs based on feeding rate using the same model organism and experimental setup. Based on comparative metal oxide NPs toxicities, the present results contribute to the knowledge related to the ecotoxicological effects of CeO2 NPs in terrestrial invertebrates exposed through feeding.


CeO2 CoFe2O4 Digestive Gland Risk Quotient Cerium Dioxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors thank M. Hočevar for SEM images of nanoparticles taken at the Institute of Metals and Technology in Ljubljana, Slovenia. The present work was funded via the European Commission 7th Framework Programme project “NanoMILE” (contract no. NMP4-LA-2013-310451). A part of work was conducted at Center of excellence in Nanoscience and Nanotechnology, Ljubljana, Slovenia.

Supplementary material

244_2017_363_MOESM1_ESM.doc (915 kb)
Supplementary material 1 (DOC 914 kb)


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.University of Nova GoricaNova GoricaSlovenia
  2. 2.Department of Biology, Biotechnical FacultyUniversity of LjubljanaLjubljanaSlovenia
  3. 3.National Institute of ChemistryLjubljanaSlovenia
  4. 4.Institute of Nuclear Sciences - VinčaBeogradSerbia

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