Abstract
The aim of this study was to assess the use of aldehyde indicator pads for detection of glutaraldehyde and alkaline glutaraldehyde permeation through chemical protective gloves under simulated in-use conditions. The quantitative analysis of glutaraldehyde permeation through a glove material was determined for Metricide, Wavicide, and 50% glutaraldehyde following a solvent-desorption process and gas chromatographic analysis. All glutaraldehyde solutions exhibited >99% adsorption (including both the glutaraldehyde oligomers of the reaction product and the excess glutaraldehyde) on the pads over the spiking range 0.05–5.0 μL. Breakthrough times for protective gloves were determined using the Thermo-Hand test method, and found to range from 76 to 150, from 170 to 230, and from 232 to 300 min for Metricide, Wavicide, and 50% glutaraldehyde, respectively. Glutaraldehyde recovery was calculated and ranged from 61 to 80% for all glutaraldehyde solutions. The mass of glutaraldehyde in these solutions at the time of breakthrough detection ranged from 17 to 18, from 18 to 19, and from 19 to 20 μg/cm2 for Wavicide, 50% glutaraldehyde solution, and Metricide, respectively. Aldehyde indicator pads and the Thermo-Hand test method together should find utility in detecting, collecting, and quantitatively analyzing glutaraldehyde permeation samples through chemical protective gloves under simulated in-use conditions.
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Acknowledgments
This work was conducted as part of the National Occupational Research Agenda (NORA) Dermal Exposure Research Program. The authors express their sincere appreciation to Quynh-Giao Nguyen, Jennifer Nguyen Vo, and Elaine Nguyen Vo for their valuable support.
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The findings and conclusions in this paper are those of the authors and do not necessarily represent the views of the National Institute for Occupational Safety and Health (NIOSH). Mention of company names or products does not constitute endorsement by the NIOSH.
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Vo, E., Zhuang, Z. The Use of Aldehyde Indicators to Determine Glutaraldehyde and Alkaline Glutaraldehyde Contamination in Chemical Protective Gloves. Arch Environ Contam Toxicol 57, 185–192 (2009). https://doi.org/10.1007/s00244-009-9316-9
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DOI: https://doi.org/10.1007/s00244-009-9316-9