This is a preview of subscription content, log in via an institution to check access.
Data availability
No datasets were generated or analysed during the current study.
References
Choy WH, Adler A, Morgan-Lang C, Gough EK, Hallam SJ et al (2024) Deficient butyrate metabolism in the intestinal microbiome is a potential risk factor for recurrent kidney stone disease. Urolithiasis 52(1):38. https://doi.org/10.1007/s00240-024-01534-x
Ellison JS, Atkinson SN, Hayward M, Hokanson E, Sheridan KR, Salzman N (2024) The intestinal microbiome of children with initial and recurrent nephrolithiasis: a pilot study and exploratory analysis. J Pediatr Urol 20(1):18–25. https://doi.org/10.1016/j.jpurol.2023.09.015
Sun SS, Wang K, Ma K, Bao L, Liu HW (2019) An insoluble polysaccharide from the sclerotium of Poria cocos improves hyperglycemia, hyperlipidemia and hepatic steatosis in ob/ob mice via modulation of gut microbiota. Chin J Nat Med 17(1):3–14. https://doi.org/10.1016/S1875-5364(19)30003-2
Acknowledgements
This work has not been presented anywhere else.
Funding
None.
Author information
Authors and Affiliations
Contributions
Conceptualization: Fu-Xiang Lin and Zhan-Ping Xu are contributing to the conceptual framework of the study, focusing on the implications of deficient butyrate metabolism in the gut microbiome as a risk factor for recurrent kidney stone disease.Literature review and analysis: Fu-Xiang Lin and Zhan-Ping Xu have critically reviewed and analyzed the research by Choy et al. alongside additional relevant literature, synthesizing information about the connection between gut microbiome dysbiosis and kidney stone development.Commentary writing: Fu-Xiang Lin took the lead in drafting the correspondence, offering insights based on the existing scientific findings and proposing directions for future research.Data interpretation: Fu-Xiang Lin and Zhan-Ping Xu interpreted the results from Choy et al.‘s study and other cited works, highlighting the significance of reduced butyrate production and its impact on the intestinal barrier integrity, which may exacerbate oxalate absorption and kidney stone recurrence.Research proposal: Zhan-Ping Xu, as the corresponding author, have played a pivotal role in suggesting ways to improve future research design, including expanding cohort sizes, controlling for confounding factors, and incorporating advanced molecular profiling techniques to validate the role of butyrate metabolism in kidney stone disease.Critical appraisal: Fu-Xiang Lin and Zhan-Ping Xu appraised the strengths and limitations of current knowledge, advocating for a more thorough investigation of the interplay between the gut microbiome and kidney stone disease progression.Correspondence handling: As the corresponding author, Zhan-Ping Xu would have handled the submission process and subsequent communications regarding the correspondence piece.Final approval: Both Fu-Xiang Lin and Zhan-Ping Xu gave their final approval for the content of the correspondence before submission for publication and agreed to its public dissemination.
Corresponding author
Ethics declarations
Statement of ethics
The authors have no ethical conflicts to disclose.
Informed consent
All authors consent to the publication of the article.
Conflicts of interest
The authors have no conflicts of interest to declare.
Competing interests
The authors declare no competing interests.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This commentary refers to the article provided at https://doi.org/10.1007/s00240-024-01534-x.
Rights and permissions
About this article
Cite this article
Lin, FX., Xu, ZP. Deficient butyrate metabolism in the gut microbiome: an emerging risk factor for recurrent kidney stone disease. Urolithiasis 52, 47 (2024). https://doi.org/10.1007/s00240-024-01558-3
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s00240-024-01558-3