Skip to main content
Log in

How important urolithiasis is under 2 years of age?

  • Original Paper
  • Published:
Urolithiasis Aims and scope Submit manuscript

Abstract

Urolithiasis (UL) is a common health problem in the world and the observed incidence of this disease is increasing in the infantile period. The study included cases of UL diagnosed before the age of two who had a comprehensive analysis for possible etiologic variables and were followed for a minimum of 6 months. Of the 60 patients included in the study, 37 were male, and the male/female ratio was 1.6. The average age at diagnosis is 8.5 ± 4.5 months. Of the cases diagnosed 41 (68.3%) were before than 1 year of age. The average time for follow-up is 28.9 ± 22.6 months. There was a family history of stone disease in 41 (68.3%) cases. Twenty-four (40%) patients were treated for dehydration at least once before stone disease was identified. The number of patients presenting with symptoms is 43 (71.7%). Restlessness was noted as the main symptom. In 17 (28.3%) patients, stone disease was found incidentally. Metabolic causes (n: 19, 31.6%) were determined to be the most common underlying cause, followed by UTI-related causes (n: 12, 20%). During the follow-up, 57 (64%) of the stones spontaneously disappeared. The size of 16 (18%) stones reduced, while the size of eleven remained same (13%). Following their absence, nine (15%) of the stones reappeared. The essential strategy is to identify high-risk groups, to closely monitor them, and to take preventative interventions against modifiable conditions such as dehydration if possible.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Clayton DB, Pope JC (2011) The increasing pediatric stone disease problem. Ther Adv Urol 3:3–12

    Article  CAS  Google Scholar 

  2. VanDervoort K, Wiesen J, Frank R, Vento S, Crosby V, Chandra M et al (2007) Urolithiasis in pediatric patients: a single center study of incidence, clinical presentation and outcome. J Urol 177:2300

    Article  Google Scholar 

  3. Mohamed J, Riadh M, Abdellatif N (2007) Urolithiasis in infants. Pediatr Surg Int 23(4):295–299

    Article  Google Scholar 

  4. Coward RJ, Peters CJ, Duffy PG, Corry D, Kellett MJ, Choong S, van’t Hoff WG (2003) Epidemiology of paediatric renal stone disease in the UK. Arch Dis Child 88(11):962–965

    Article  CAS  Google Scholar 

  5. Dursun I, Poyrazoglu HM, Dusunsel R, Gunduz Z, Gurgoze MK, Demirci D, Kucukaydın M (2008) Pediatric urolithiasis: an 8-year experience of single centre. Int Urol Nephrol 40(1):3–9

    Article  Google Scholar 

  6. Alpay H, Ozen A, Gokce I (2009) Biyikli N Clinical and metabolic features of urolithiasis and microlithiasis in children. Pediatr Nephrol 24:2203–2209

    Article  Google Scholar 

  7. Bek K, Akman S, Bilge I, Topaloğlu R, Çalışkan S, Peru H, Cengiz N, Söylemezoğlu O (2009) Chronic kidney disease in children in Turkey. Pediatr Nephrol 24(4):797–806

    Article  Google Scholar 

  8. Sirin A, Emre S, Alpay H, Nayır A, Bilge I, Tanman F (1995) Etiology of chronic renal failure in Turkish children. Pediatr Nephrol 9(5):549–552

    Article  CAS  Google Scholar 

  9. Baştuğ F, Gündüz Z, Tülpar S, Poyrazoğlu H, Düşünsel R (2013) Urolithiasis in infants: evaluation of risk factors. World J Urol 31:1117–1122

    Article  Google Scholar 

  10. Scoffone CM, Cracco CM (2018) Pediatric calculi: cause, prevention and medical management. Curr Opin Urol 28(5):428–432

    Article  Google Scholar 

  11. Edvardsson V (2016) Urolithiasis in Children. In: Avner ED, Harman WE, Niaudet P, Yoshikawa N, Emma F, Goldstein SL (eds) Pediatr Nephrol. 7th edn: 1821–1868

  12. Chimenz R, Cannavo L, Viola V, Benedetto VD, Scuderi MG, Pensabene L et al (2019) Pediatric urolithiasis. J Biol Regul Homeost Agents 33(5 suppl. 1):39–44

    CAS  PubMed  Google Scholar 

  13. Edvardsson V, Elidottir H, Indridason OS, Palsson R (2005) High incidence of kidney stones in Icelandic children. Pediatr Nephrol 20(7):940–944

    Article  Google Scholar 

  14. Ozokutan BH, Kucukaydin M, Gunduz Z, Kabaklioglu M, Okur H, Turan C (2000) Urolithiasis in childhood. Pediatr Surg Int 16(1–2):60–63

    CAS  PubMed  Google Scholar 

  15. Erbagci A, Erbagci AB, Yilmaz M, Yagci F, Tarakcioglu M, Yurtseven C et al (2003) Pediatric urolithiasis evaluation of risk factors in 95 children. Scand J Urol Nephrol 37(2):129–133

    Article  CAS  Google Scholar 

  16. Serdaroğlu E, Aydoğan M, Özdemir K, Bak M (2017) Incıdence and causes of urolithiasis in children between 0–2 years. Minerca Urol e Nefrol 69(2):181–188

    Google Scholar 

  17. Güven A, Koyun M, Baysal YE, Akman S, Alimoflu E (2010) Akbas H et al Urolithiasis in the first year of life. Pediatr Nephrol 25:129–134

    Article  Google Scholar 

  18. Milliner DS. Urolithiasis. In: Avner ED, Harman WE, Niaudet P, Yoshikawa N (eds) (2009) Pediatr Nephrol. 6th edn: 1405–1430

  19. Kammon A, Daudon M, Abdelmoula J, Hamzoui M, Chaouchi B, Houissa T et al (1999) Urolithiasis in Tunisian children: a study of 120 cases based on stone composition. Pediatr Nephrol 13:920–925

    Article  Google Scholar 

  20. Mitra N (2015) Urolithiasis in the first two months of life. Iran J Kidney Dis 9(5):379–386

    Google Scholar 

  21. Sas DJ, Becton LJ, Tutman J, Lindsay LA, Wahlquist AH (2016) Clinical, demographic, and laboratory characteristics of children with nephrolithiasis. Urolithiasis 44(3):241–246

    Article  CAS  Google Scholar 

  22. Shahta HA (2005) Etiological and clinical patterns of childhood urolithiasis in Iraq. Ped Nephrol 20(10):1453–1457

    Article  Google Scholar 

  23. Amancio L, Fedrizzi M, Bresolin NL, Penido MG (2016) Pediatric urolithiasis: experience at a tertiary care pediatric hospital. J Bras Nefrol 38(1):90–98

    Article  Google Scholar 

  24. Celiksoy MH, Yilmaz A, Aydogan G, Kıyak A, Topal E, Sander S (2015) Metabolic disorders in Turkish children with urolithiasis. Urology 85(4):909–913

    Article  Google Scholar 

  25. Ertan P, Tekin G, Oger N, Alkan S, Horasan GD (2011) Metabolic and demographic characteristics of children with urolithiasis in Western Turkey. Urol Res 39:105–110

    Article  Google Scholar 

  26. Alemzadeh-Ansari MH, Valavi E, Ahmadzadeh A (2014) Predisposing factors for infantile urinary calculus in south-west of Iran. Iran J Kidney Dis 8(1):53–57

    PubMed  Google Scholar 

  27. Spivacow FR, Negri AL, Del Valle EE, Calviño I, Fradinger E, Zanchetta JR (2008) Metabolic risk factors in children with kidney stone disease. Pediatr Nephrol 23:1129–1133

    Article  Google Scholar 

  28. Katarzyna J, Magda R, Aleksandra P (2018) Urolithiasis in the pediatric population-current opinion on epidemiology, patophysiology, diagnostic evaluation and treatment. Dev Period Med 22(2):201–208

    Google Scholar 

  29. Baştuğ F, Düşünsel R (2012) Pediatric urolithiasis: causative factors, diagnosis and medical management. Nat Rev Urol 9:138–146

    Article  Google Scholar 

  30. Diamond DA (1991) Clinical patterns of pediatric urolithiasis. Br J Urol 68:195–198

    Article  CAS  Google Scholar 

  31. Basaklar AC, Kale N (1991) Experience with childhood urolithiasis. Report of 196 cases. Br J Urol 67:203–205

    Article  CAS  Google Scholar 

  32. Alpay H, Gokce I, Ozen A, Bıyıklı N (2013) Urinary stone disease in the first year of life: is it dangerous? Pediatr Surg Int 29:311–316

    Article  Google Scholar 

  33. Bak M, Ural R, Agin H, Serdaroglu E, Calkavur S (2009) The metabolic etiology of urolithiasis in Turkish children. Int Urol Nephrol 41:453–460

    Article  CAS  Google Scholar 

  34. Polinsky MS, Kaiser BA, Baluarte HJ (1987) Urolithiasis in childhood. Pediatr Clin North Am 34:683–710

    Article  CAS  Google Scholar 

Download references

Funding

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Aysun Çaltik Yilmaz.

Ethics declarations

Conflict of interest

None.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Çaltik Yilmaz, A., Ünal, N., Çelebi Tayfur, A. et al. How important urolithiasis is under 2 years of age?. Urolithiasis 50, 159–165 (2022). https://doi.org/10.1007/s00240-021-01295-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00240-021-01295-x

Keywords

Navigation