, Volume 46, Issue 6, pp 543–547 | Cite as

Uric acid stones increase the risk of chronic kidney disease

  • Ching-Chia Li
  • Tsu-Ming Chien
  • Wen-Jeng Wu
  • Chun-Nung Huang
  • Yii-Her ChouEmail author
Original Paper


The aim of this study was to compare the clinical characteristics of uric acid stones and their potential risk for chronic kidney disease (CKD). A total of 401 patients (196 with uric acid stone and 205 without) were enrolled from our database of patients with urolithiasis. We analyzed the clinical demographic features, stone location, urine chemistries, and renal function. There was a significant difference (p < 0.001) between the two groups in terms of age, with the higher mean age in the uric acid group. Patients with uric acid stones had much lower pH of urine (p < 0.001) and higher serum uric acid level (p = 0.002). Notably, those with uric acid stones had worse eGFR than those with non-uric acid stones. Multivariate analysis confirmed that age over 60 years (ORs = 9.19; 95% CI 3.5–24.3), female sex (ORs = 4.01; 95% CI 1.8-9.0), hyperuricemia (ORs = 8.47; 95% CI 1.6–43.5), and uric acid stone (OR = 2.86; 95% CI 1.2–6.7) were the independent predictors of poor prognoses in CKD. Therefore, an association exists between uric acid stones and higher prevalence of CKD. Patients with uric acid stones may need close monitoring of renal function during follow-up.


Urinary calculi Uric acid Chronic kidney disease 


Compliance with ethical standards

Conflict of interest

We declare no conflict of interest.

Ethical approval

All procedures performed were in accordance with the ethical standards of the institutional and/or national research committee, and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

For this type of study, formal consent is not required.

Supplementary material

240_2018_1050_MOESM1_ESM.docx (13 kb)
Supplementary material 1 (DOCX 12 KB)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Ching-Chia Li
    • 1
    • 2
  • Tsu-Ming Chien
    • 1
    • 2
  • Wen-Jeng Wu
    • 1
    • 2
    • 3
  • Chun-Nung Huang
    • 1
    • 2
    • 3
  • Yii-Her Chou
    • 1
    • 2
    Email author
  1. 1.Department of UrologyKaohsiung Medical University HospitalKaohsiungTaiwan
  2. 2.Department of Urology, School of Medicine, College of MedicineKaohsiung Medical UniversityKaohsiungTaiwan
  3. 3.Department of UrologyKaohsiung Municipal Ta-Tung HospitalKaohsiungTaiwan

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