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Urolithiasis

, Volume 46, Issue 2, pp 211–218 | Cite as

Role of silodosin as medical expulsive therapy in ureteral calculi: a meta-analysis of randomized controlled trials

  • Xin-Jian Liu
  • Jian-Guo Wen
  • You-Dong Wan
  • Bo-Wen Hu
  • Qing-Wei Wang
  • Yan Wang
Original Paper

Abstract

The objective of this study is to investigate the efficacy of silodosin in medical expulsive therapy (MET) for ureteral stones. We conducted a systematic review and meta-analysis to determine the efficacy and safety of silodosin in MET for ureteral calculi. We searched PubMed, Embase, Medline, Central (the Cochrane Library, Issue 1,2013), Google Scholar from the inception to March 2015 for randomized controlled trials (RCTs), comparing silodosin with tamsulosin or control on ureteral stone passage. Eight RCTs with a total of 1145 ureteral stone patients (300 patients in the control group, 287 patients in the tamsulosin group, 558 patients in the silodosin group) were included in this meta-analysis. When compared with control, silodosin significantly improved expulsion rate of distal ureteral stones (RR: 1.42; 95% CI, 1.21–1.67; P < 0.0001), while there was no significant difference between silodosin and the control in expulsion rate of proximal (RR: 0.99; 95% CI, 0.69–1.43; P < 0.97) or mid (RR: 1.13; 95% CI, 0.60–2.16; P < 0.0001) ureteral stones. There was no significant difference between silodosin and tamsulosin in terms of expulsion time (WMD: −2.47; 95% CI, −5.32 to 0.39; P = 0.09), analgesic use (WMD: −0.39; 95% CI, −0.91 to 0.13; P  = 0.14) and retrograde ejaculation rate (RR: 1.85; 95% CI, 0.95–3.59; P = 0.07) in MET for distal ureteral stones. However, silodosin provided a significantly higher expulsion rate (RR: 1.25; 95% CI, 1.13–1.37; P < 0.0001) than tamsulosin for distal ureteral stones. Silodosin significantly improved expulsion rate of distal ureteral stones and was clinically superior to tamsulosin. Silodosin was ineffective in MET for proximal and mid ureteral stones. More RCT studies are needed to compare the efficacy of silodosin versus tamsulosin in MET for distal ureteral stones.

Keywords

Silodosin Tamsulosin Medical expulsive therapy Ureteral stones Expulsion rate 

Notes

Compliance with ethical standards

Funding

This study was funded by the National Natural Science Foundation (Grant number 81,370,869).

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Xin-Jian Liu
    • 1
  • Jian-Guo Wen
    • 1
  • You-Dong Wan
    • 2
  • Bo-Wen Hu
    • 3
  • Qing-Wei Wang
    • 1
  • Yan Wang
    • 1
  1. 1.Department of Urodynamic Centre and UrologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina
  2. 2.Department of Integrated Intensive Care UnitThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina
  3. 3.Department of Hepatobiliary and Pancreatic SurgeryThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

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