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The utility of diffusion-weighted imaging to assess acute renal parenchymal changes due to unilateral ureteral stone obstruction

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Abstract

Our aim in this study was to evaluate the use of diffusion-weighted imaging (DWI) for acute renal parenchymal changes occurring as a result of unilateral ureteral obstruction due to stones. Twenty four patients with obstructed and opposite unobstructed kidney were enrolled in this prospective study. DWI was used at two different b values (b = 0 s/mm2 and b = 1000 s/mm2). Apparent diffusion coefficient (ADC) measurements were completed on the upper pole, central section and lower pole parenchyma of both kidneys. ADC values were calculated. The unpaired t test was used to assess differences between the groups. The results of measurements identified a reduction in ADC values in obstructed renal parenchyma compared to unobstructed opposite renal parenchyma. The reduction in ADC values was greater in the upper and lower pole parenchyma and was statistically significant (p < 0.001, for both). Diffusion changes in renal parenchyma due to acute unilateral ureteral obstruction linked to stone may be quantitatively shown with DWI. The reduction in ADC values was more pronounced in the upper and lower pole parenchyma.

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References

  1. Vaughan ED Jr, Marion D, Poppas DP, Felsen D (2004) Pathophysiology of unilateral ureteral obstruction: studies from Charlottesville to New York. J Urol 172:2563–2569

    Article  CAS  PubMed  Google Scholar 

  2. Thoeny HC, De Keyzer F, Oyen RH, Peeters RR (2005) Diffusion-weighted MR imaging of kidneys in healthy volunteers and patients with parenchymal diseases: initial experience. Radiology 235:911–917

    Article  PubMed  Google Scholar 

  3. Namimoto T, Yamashita Y, Mitsuzaki K, Na-kayama Y, Tang Y, Takahashi M (1999) Measurement of the apparent diffusion coefficient in diffuse renal disease by diffusion-weighted echo-planar MR imaging. J Magn Reson Imaging 9:832–837

    Article  CAS  PubMed  Google Scholar 

  4. Xu Y, Wang X, Jiang X (2007) Relationship between the renal apparent diffusion coefficient and glomerular filtration rate: preliminary experience. J Magn Reson Imaging 26:678–681

    Article  PubMed  Google Scholar 

  5. Fukuda Y, Ohashi I, Hanafusa K, Nakagawa T, Ohtani S, An-naka Y, Hayashi T, Shibuya H (2000) Anisotropic diffusion in kidney: apparent diffusion coefficient measurements for clinical use. J Magn Reson Imaging 11:156–160

    Article  CAS  PubMed  Google Scholar 

  6. Siegel CL, Aisen AM, Ellis JH, Londy F, Chenevert TL (1995) Feasibility of MR diffusion studies in the kidney. J Magn Reson Imaging 5:617–620

    Article  CAS  PubMed  Google Scholar 

  7. Kiliçkesmez O, Yirik G, Bayramoglu S, Cimilli T, Aydin S (2008) Non-breath-hold high b-value diffusion-weighted MRI with parallel imaging technique: apparent diffusion coefficient determination in normal abdominal organs. Diagn Interv Radiol 14:83–87

    PubMed  Google Scholar 

  8. Toyoshima S, Noguchi K, Seto H, Shimizu M, Watanabe N (2000) Functional evaluation of hydronephrosis by diffusion-weighted MR imaging. Relationship between apparent diffusion coefficient and split glomerular filtration rate. Acta Radiol 4:642–646

    Article  Google Scholar 

  9. Cova M, Squillaci E, Stacul F et al (2004) Diffusion-weighted MRI in the evaluation of renal lsions: preliminary results. Br J Radiol 77:851–857

    Article  CAS  PubMed  Google Scholar 

  10. Muller MF, Prasad PV, Bimmler D, Kaiser A, Edelman RR (1994) Functional imaging of the kidney by means of measurement of the apparent diffusion coefficient. Radiology 193:711–715

    Article  CAS  PubMed  Google Scholar 

  11. Pedersen M, Wen JG, Shi Y et al (2003) The effect of unilateral ureteral obstruction on renal function in pigs measured by diffusion-weighted MRI. APMIS 109:29–34

    Google Scholar 

  12. Thoeny HC, Binser T, Roth B, Kessler TM, Vermathen P (2009) Noninvasive assessment of acute ureteral obstruction with diffusion-weighted MR imaging: a prospective study. Radiology 252:721–728

    Article  PubMed  Google Scholar 

  13. Bozgeyik Z, Kocakoc E, Sonmezgoz F (2009) Diffusion-weighted MR imaging findings of kidneys in patients with early phase of obstruction. Eur J Radiol 70:138–141

    Article  PubMed  Google Scholar 

  14. Soylu Boy FN, Kayhan A, Karakas HM, Alp T, Verit A (2015) Diffusion-weighted MR imaging and Doppler ultrasonography in the evaluation of renal parenchyma in acute ureteral obstruction. Int J Clin Exp Med 8:2719–2726

    PubMed  PubMed Central  Google Scholar 

  15. Müller MF, Prasad P, Siewert B, Nissenbaum MA, Raptopoulos V, Edelman RR (1994) Abdominal diffusion mapping with use of a whole-body echo-planar system. Radiology 190:475–478

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Faculty of Medicine, Inonu University, Elazig Road, 15 km., 44100, Malatya, Turkey

    Kürşat Düzenli, İsmail Okan Yıldırım & Gülnur Erdem

  2. Diyarbakır Children’s Hospital, 21100, Diyarbakır, Turkey

    Mehmet Öztürk

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  1. Kürşat Düzenli
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  2. Mehmet Öztürk
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  3. İsmail Okan Yıldırım
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  4. Gülnur Erdem
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Correspondence to Mehmet Öztürk.

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Düzenli, K., Öztürk, M., Yıldırım, İ.O. et al. The utility of diffusion-weighted imaging to assess acute renal parenchymal changes due to unilateral ureteral stone obstruction. Urolithiasis 45, 401–405 (2017). https://doi.org/10.1007/s00240-016-0924-3

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  • DOI: https://doi.org/10.1007/s00240-016-0924-3

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