The value of hypercalciuria in patients with osteopenia versus osteoporosis
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The aim of this study was to analyze the presence of lithogenic metabolic factors in the blood and urine of patients with osteopenia versus osteoporosis. This is a cross-sectional study including 67 patients who were divided into two groups according to the presence of either osteopenia or osteoporosis as measured by bone densitometry: group 1—40 patients with osteopenia (22 men and 18 women) and group 2—27 patients with osteoporosis (13 men and 14 women). Metabolic studies were performed on the blood and urine; statistical analysis was performed comparing means and conducting linear correlation and multivariate analyses with SPSS. Statistical significance was considered to be p ≤ 0.05. The mean age of patients in group 1 was 52.9 ± 12.8 years versus 50.3 ± 11.4 in group 2; the difference was not statistically significant. In group 2, higher levels of osteocalcin, β-crosslaps, urinary calcium, fasting urine calcium/creatinine, 24 h urine calcium/creatinine and 24 h oxaluria were observed compared to group 1. In the multivariate analysis, only the β-crosslaps and urinary calcium were independently associated with osteoporosis. It would be advisable to determine the urinary calcium levels in patients with osteoporosis since altered levels may necessitate modifying the diagnostic and therapeutic approach to osteoporosis.
KeywordsOsteopenia Osteoporosis Bone markers Calciuria
This article is a part of doctoral thesis by Maria Sierra Girón-Prieto in the Doctorado of Medicina Clinica and Salud Publica. Granada University. This investigation has been funded by Fundacion Progreso y Salud. Consejeria de Salud. Junta de Andalucia. Pi 0766/2013.
Compliance with ethical standards
It is a low ethically responsible study in which the patients gave their informed consent after reading the Patient Information Sheet. The study was approved by the Hospital Ethics Committee.
Conflict of interest
The authors have no conflicts of interest to report.