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Association of vitamin D receptor gene polymorphism and calcium urolithiasis in the Chinese Han population

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Abstract

To investigate the effect of the vitamin D receptor (VDR) Fok I Bsm I Dde I Apa I Taq I polymorphism on the clinical presentation of calcium urolithiasis, 464 patients with urolithiasis and 450 age- and sex-matched healthy controls were recruited from The First Affiliated Hospital of Zhejiang University between January 2010 and March 2011. Five SNPs of VDR polymorphism were detected using polymerase chain reaction-based restriction analysis. The frequency of VDR Apa I genotypes between the patients and the healthy controls was significantly different (P = 0.006). Apa I a allele was found to be associated with increased risk of stone recurrence (P = 0.028). We also found Fok I Dde I Apa I showed a significant difference between male and female in the patients group (P < 0.05). Haplotype analysis of the five VDR polymorphisms showed a significant association with urolithiasis (global-P value = 0.0001). Genetic polymorphisms of VDR are important in the clinical presentation of patients with calcium urolithiasis in the Han population of southern China.

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Acknowledgments

This study was supported by grants from the National Natural Science Foundation of China (Grant No. 30801370).

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Authors and Affiliations

  1. Department of Urology, School of Medicine, The First Affiliated Hospital, Zhejiang University, Qingchun Road 79, Hangzhou, 310003, Zhejiang Province, China

    Shuai Wang, Xiao Wang, Jian Wu, Yiwei Lin, Hong Chen, Xiangyi Zheng, Cheng Zhou & Liping Xie

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  1. Shuai Wang
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  2. Xiao Wang
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  3. Jian Wu
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  8. Liping Xie
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Correspondence to Liping Xie.

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Wang, S., Wang, X., Wu, J. et al. Association of vitamin D receptor gene polymorphism and calcium urolithiasis in the Chinese Han population. Urol Res 40, 277–284 (2012). https://doi.org/10.1007/s00240-011-0438-y

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  • DOI: https://doi.org/10.1007/s00240-011-0438-y

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