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Difference in urinary stone components between obese and non-obese patients

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Abstract

The prevalence and incidence of urinary stone disease have been reported to be associated with body weight and body mass index (BMI). The aim of the study was to determine the difference in stone components among different BMI groups in patients with urolithiasis. Between Dec 2005 and Jan 2008, 907 urinary calculi were collected and analyzed by infrared spectroscopy. Most of the stones had been passed spontaneously, and some were collected during surgical manipulations. The data on patients’ gender, age, BMI at diagnosis, and stone composition were collected. The patients were classified as normal weight (18.5≤ BMI <24), overweight (24≤ BMI <27), or obese (BMI ≥27). Of the 907 patients with urinary stone disease, 27.7% had normal weight, 33.5% were overweight, and 38.8% were obese. The prevalence of calcium oxalate stones in the normal weight, overweight, and obese groups were 23.1, 30.6, and 34.9%, respectively (P = 0.002), and the prevalence of uric acid stones in the different groups was 2.8, 7.2, and 7.7%, respectively (P = 0.002). The prevalence of calcium oxalate and uric acid stones, but not that of calcium phosphate stones, increased with body size. There was a significant correlation between BMI and uric acid stones in the overweight and obesity groups, with odds ratios of 3.28 and 4.35, respectively. The prevalence and incidence of urinary stone disease were found to be associated with BMI. The percentage of uric acid and calcium oxalate stones was higher in obese than in non-obese patients. There was no apparent difference in the prevalence of calcium phosphate stones between obese and non-obese patients.

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References

  1. Stamatelou KK, Francis ME, Jones CA, Nyberg LM, Curhan GC (2003) Time trends in reported prevalence of kidney stones in the United States: 1976–1994. Kidney Int 63:1817–1823

    Article  PubMed  Google Scholar 

  2. Johnson CM, Wilson DM, O′Fallon WM, Malek RS, Kurland LT (1979) Renal stone epidemiology: a 25-year study in Rochester, Minnesota. Kidney Int 16:624–631

    Article  PubMed  CAS  Google Scholar 

  3. Yoshida O, Terai A, Ohkawa, Okada Y (1999) National trend of the incidence of urolithiasis in Japan from 1965 to 1995. Kidney Int 56:1899–1904

    Article  PubMed  CAS  Google Scholar 

  4. Curhan GC, Willett WC, Rimm EB, Speizer FE, Stampfer MJ (1998) Body size and risk of kidney stones. J Am Soc Nephrol 9:1645–1652

    PubMed  CAS  Google Scholar 

  5. Flegal KM, Carroll MD, Ogden CL, Johnson CL (2002) Prevalence and trends in obesity among US adults 1999–2000. JAMA 288:1723–1727

    Article  PubMed  Google Scholar 

  6. Kopelman PG (2000) Obesity as a medical problem. Nature 404:635–643

    PubMed  CAS  Google Scholar 

  7. Taylor EN, Stampfer MJ, Curhan GC (2005) Obesity, weight gain, and the risk of kidney stones. JAMA 293:455–462

    Article  PubMed  CAS  Google Scholar 

  8. Choo V (2002) WHO reassesses appropriate body-mass index for Asian populations. Lancet 360:235

    Article  PubMed  Google Scholar 

  9. Coe FL, Parks JH, Asplin JR (1992) The pathogenesis and treatment of kidney stones. N Engl J Med 327:1141–1152

    Article  PubMed  CAS  Google Scholar 

  10. Levy FL, Adams-Huet B, Pak CY (1995) Ambulatory evaluation of nephrolithiasis: an update of a 1980 protocol. Am J Med 98:50–59

    Article  PubMed  CAS  Google Scholar 

  11. Lee SC, Kim YJ, Kim TH, Yun SJ, Lee NK, Kim WJ (2008) Impact of obesity in patients with urolithiasis and its prognostic usefulness in stone recurrence. J Urol 179:570–574

    Article  PubMed  Google Scholar 

  12. Sarica K, Altay B, Erturhan S (2008) Effect of being overweight on stone-forming risk factors. Urology 71:771–774

    Article  PubMed  Google Scholar 

  13. Duffey BG, Pedro RN, Kriedberg C, Weiland D, Melquist J, Ikramuddin S et al (2008) Lithogenic risk factors in the morbidly obese population. J Urol 179:1401–1406

    Article  PubMed  CAS  Google Scholar 

  14. Obligado SH, Goldfarb DS (2008) The association of nephrolithiasis with hypertension and obesity: a review. Am J Hypertens 21:257–264

    Article  PubMed  CAS  Google Scholar 

  15. Zilberman DE, Yong D, Albala DM (2009) The impact of societal changes on patterns of urolithiasis. Curr Opin Urol 20:148–153

    Article  Google Scholar 

  16. Asplin JR (2009) Obesity and urolithiasis. Adv Chronic Kidney Dis 16:11–20

    Article  PubMed  Google Scholar 

  17. Eisner BH, Eisenberg ML, Stoller ML (2009) Influence of body mass index on quantitative 24-hour urine chemistry studies in children with nephrolithiasis. J Urol 182:1142–1145

    Article  PubMed  CAS  Google Scholar 

  18. Scales CD Jr, Curtis LH, Norris RD, Springhart WP, Sur RL, Schulman KA et al (2007) Changing gender prevalence of stone disease. J Urol 177:979–982

    Article  PubMed  Google Scholar 

  19. Strope SA, Wolf JS Jr, Hollenbeck BK (2009) Changes in gender distribution of urinary stone disease. Urology 75:543–546

    Article  PubMed  Google Scholar 

  20. Powell CR, Stoller ML, Schwartz BF, Kane C, Gentle DL, Bruce JE et al (2005) Impact of body weight on urinary electrolytes in urinary stone former. Urology 55(6):825–830

    Article  Google Scholar 

  21. Li WM, Chou YH, Li CC, Liu CC, Huang SP, Wu WJ et al (2009) Association of body mass index and urine pH in patients with urolithiasis. Urol Res 37:193–196

    Article  PubMed  Google Scholar 

  22. Maalouf NM, Sakhaee K, Parks JH, Coe FL, Adam-Huet B, Pak CY (2004) Association of urinary pH with body weight in nephrolithiasis. Kidney Int 65:1422–1425

    Article  PubMed  Google Scholar 

  23. Sakhaee K, Maalouf NM (2008) Metabolic syndrome and uric acid nephrolithiasis. Semin Nephrol 28:174–180

    Article  PubMed  CAS  Google Scholar 

  24. Cameron MA, Sakhaee K (2007) Uric acid nephrolithiasis. Urol Clin North Am 34:335–346

    Article  PubMed  Google Scholar 

  25. Kamel KS, Cheema-Dhadli S, Halperin ML (2002) Studies on the pathophysiology of the low urine pH in patients with uric acid stones. Kidney Int 61:988–994

    Article  PubMed  CAS  Google Scholar 

  26. Abate N, Chandalia M, Cabo-Chan AV Jr, Moe OW, Sakhaee K et al (2004) The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance. Kidney Int 65:386–392

    Article  PubMed  CAS  Google Scholar 

  27. Daudon M, Traxer O, Conort P, Lacour B, Jungers P (2006) Type 2 diabetes increases the risk for uric acid stones. J Am Soc Nephrol 17:2026–2033

    Article  PubMed  CAS  Google Scholar 

  28. Pak CY, Sakhaee K, Moe O, Preminger GM, Poindexter JR, Peterson RD et al (2003) Biochemical profile of stone-forming patients with diabetes mellitus. Urology 61:523–527

    Article  PubMed  Google Scholar 

  29. Grases F, Sanchis P, Perello J, Maser-Gluth C, Remer T (2006) Role of uric acid in different types of calcium oxalate renal calculi. Int J Urol 13:252–256

    Article  PubMed  CAS  Google Scholar 

  30. Grover PK, Ryall RL (2005) Critical appraisal of salting-out and its implications for chemical and biological sciences. Chem Rev 105:1–10

    Article  PubMed  CAS  Google Scholar 

  31. Shi L, Berkemeyer S, Buyken AE, Maser-Gluth C, Remer T (2010) Glucocorticoids and body fat associated with renal uric acid and oxalate, but not calcium excretion, in healthy children. Metabolism 59(1):134–139

    Article  PubMed  CAS  Google Scholar 

  32. Negri AL, Spivacow FR, Del Valle EE, Forrester M, Rosende G, Pinduli I (2008) Role of overweight and obesity on the urinary excretion of promoters and inhibitors of stone formation in stone formers. Urol Res 36:303–307

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

The authors thank the Statistical Analysis Laboratory, Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University for the help they provided. The authors also thank Miss Ai-Wen Chang and Miss Mei-Hui Lee for preparation and collection of stone analysis data.

Conflict of interest

The authors have nothing to declare.

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Authors and Affiliations

  1. Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University Hospital, No. 100 Tzyou 1st Road, Kaohsiung, 807, Taiwan

    Yii-Her Chou, Ching-Chia Li, Chia-Chu Liu, Wen-Jeng Wu & Yung-Shun Juan

  2. Department of Urology, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan

    Ching-Ming Su

  3. Graduate Institute of Medical Genetic, Kaohsiung Medical University, Kaohsiung, Taiwan

    Mu-En Liu

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  1. Yii-Her Chou
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  2. Ching-Ming Su
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Correspondence to Yii-Her Chou.

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Chou, YH., Su, CM., Li, CC. et al. Difference in urinary stone components between obese and non-obese patients. Urol Res 39, 283–287 (2011). https://doi.org/10.1007/s00240-010-0344-8

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  • DOI: https://doi.org/10.1007/s00240-010-0344-8

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