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Journal of Molecular Evolution

, Volume 53, Issue 4–5, pp 508–516 | Cite as

Maximum Likelihood Analysis of the Complete Mitochondrial Genomes of Eutherians and a Reevaluation of the Phylogeny of Bats and Insectivores

  • Masato  Nikaido
  • Kuniko  Kawai
  • Yin  Cao
  • Masashi  Harada
  • Satoru  Tomita
  • Norihiro  Okada
  • Masami  Hasegawa

Abstract.

The complete mitochondrial genomes of two microbats, the horseshoe bat Rhinolophus pumilus, and the Japanese pipistrelle Pipistrellus abramus, and that of an insectivore, the long-clawed shrew Sorex unguiculatus, were sequenced and analyzed phylogenetically by a maximum likelihood method in an effort to enhance our understanding of mammalian evolution. Our analysis suggested that (1) a sister relationship exists between moles and shrews, which form an eulipotyphlan clade; (2) chiropterans have a sister-relationship with eulipotyphlans; and (3) the Eulipotyphla/Chiroptera clade is closely related to fereuungulates (Cetartiodactyla, Perissodactyla and Carnivora). Divergence times on the mammalian tree were estimated from consideration of a relaxed molecular clock, the amino acid sequences of 12 concatenated mitochondrial proteins and multiple reference criteria. Moles and shrews were estimated to have diverged approximately 48 MyrBP, and bats and eulipotyphlans to have diverged 68 MyrBP. Recent phylogenetic controversy over the polyphyly of microbats, the monophyly of rodents, and the position of hedgehogs is also examined.

Key words: Molecular phylogeny — Chiroptera — Eulipotyphla — Fereuungulata — Complete mitochondrial genome — Maximum likelihood 

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Copyright information

© Springer-Verlag New York Inc. 2001

Authors and Affiliations

  • Masato  Nikaido
    • 1
  • Kuniko  Kawai
    • 1
  • Yin  Cao
    • 2
  • Masashi  Harada
    • 3
  • Satoru  Tomita
    • 4
  • Norihiro  Okada
    • 1
  • Masami  Hasegawa
    • 2
  1. 1.Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, JapanJP
  2. 2.Institute of Statistical Mathematics, Tokyo, JapanJP
  3. 3.Osaka City University Medical School, Osaka, JapanJP
  4. 4.Gene Research Center, Tokyo Institute of Technology, Yokohama, JapanJP

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