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Journal of Molecular Evolution

, Volume 53, Issue 4–5, pp 314–326 | Cite as

Genetic Code Variations in Mitochondria: tRNA as a Major Determinant of Genetic Code Plasticity

  • Shin-ichi  Yokobori
  • Tsutomu  Suzuki
  • Kimitsuna  Watanabe

Abstract.

Characteristic features of tRNA such as the anticodon sequence and modified nucleotides in the anticodon loop are thought to be crucial effectors for promoting or restricting codon reassignment. Our recent findings on basepairing rules between anticodon and codon in various metazoan mitochondria suggest that the complete loss of a codon is not necessarily essential for codon reassignment to take place. We postulate that a possible competition between two tRNAs with cognate anticodon sequences towards the relevant codon to be varied has a potential role in codon reassignment. Our proposition can be viewed as an expanded version of the codon capture theory proposed by Osawa and Jukes (J Mol Evol 28: 271–278, 1989).

Key words: Codon capture — tRNA — Mitochondria — Wobble rule — Competition 

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Copyright information

© Springer-Verlag New York Inc. 2001

Authors and Affiliations

  • Shin-ichi  Yokobori
    • 1
  • Tsutomu  Suzuki
    • 2
  • Kimitsuna  Watanabe
    • 2
  1. 1.Department of Molecular Biology, School of Life Science, Tokyo University of Pharmacy and Life Science, 1432 Horinouchi, Hachioji, Tokyo 192-0392, JapanJP
  2. 2.Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8656, JapanJP

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