Abstract
A compensatory mutation (CM) counter balances lethal effects of a deleterious mutation (DM), ensuring the persistence of both through natural selection. However, little is known about the biological aspects of CMs those restore the structural alterations of proteins caused by slightly DMs. Here, by analyzing the evolution of the UDP-glycosyltransferase 73B4 protein among monocot-dicot plants, we investigate the occurrence of CMs around slightly DMs in 3D space. Our results illustrate that CMs exhibit significantly higher tendency to occur within the range of electrostatic interaction around the slightly DMs, compared to occurring randomly in the protein.
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Acknowledgments
The authors acknowledge the editorial review process of the journal for many useful comments. This work was supported by the Center of Excellence in Systems Biology and Biomedical Engineering (TEQIP Phase II), University of Calcutta, India.
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Amrita Bhattacherjee and Saurav Mallik have contributed equally to the work.
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Bhattacherjee, A., Mallik, S. & Kundu, S. Compensatory Mutations Occur Within the Electrostatic Interaction Range of Deleterious Mutations in Protein Structure. J Mol Evol 80, 10–12 (2015). https://doi.org/10.1007/s00239-014-9654-8
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DOI: https://doi.org/10.1007/s00239-014-9654-8