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Journal of Molecular Evolution

, Volume 59, Issue 6, pp 827–833 | Cite as

Shedding Genomic Ballast: Extensive Parallel Loss of Ancestral Gene Families in Animals

  • Austin L. Hughes
  • Robert Friedman
Article

Abstract

Loss of ancestral gene families has played an important role in genomic specialization in animals. An examination of the pattern of gene family loss in completely sequenced animal genomes revealed that the same gene families have been lost independently in different lineages to a far greater extent than expected if gene loss occurred at random. This result implies that certain ancestral gene families—and thus the biological functions they encode—have been more expendable than others over the radiation of the animal phyla.

Keywords

Gene loss Genome evolution Parallel evolution 

Notes

Acknowledgment

This research was supported by Grant GM066710 from the National Institutes of Health to A.L.H.

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Copyright information

© Springer Science + Business Media Inc. 2004

Authors and Affiliations

  1. 1.Department of Biological SciencesUniverxsity of South Carolina, Coker Life Sciences BuildingColumbiaUSA

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