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The Shark HoxN Cluster Is Homologous to the Human HoxD Cluster

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Abstract

The statistical analysis of phylogenetic footprints in the two known horn shark Hox clusters and the four mammalian clusters shows that the shark HoxN cluster is HoxD-like. This finding implies that the most recent common ancestor of jawed vertebrates had at least four Hox clusters, including those which are orthologous to the four mammalian Hox clusters.

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Acknowledgements

Funding for this research is gratefully acknowledged: DFG Bioinformatics Initiative BIZ-6/1-2 to S.J.P., C.F., and P.F.S., NSF IBN-9905408 to F.R. and IBN-0321470 to G.P.W.

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Authors and Affiliations

  1. Bioinformatik, Institut für Informatik, Universität Leipzig, Kreuzstraßse 7b, D-04103 Leipzig, Germany

    Sonja J. Prohaska, Claudia Fried & Peter F. Stadler

  2. Institut für Theoretische Chemie und Molekulare Strukturbiologie, Universität Wien, Währingerstraße 17, A-1090 Wien, Austria

    Sonja J. Prohaska, Claudia Fried & Peter F. Stadler

  3. Molecular Genetics Department, Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA

    Chris T. Amemiya

  4. Department of Cellular and Developmental Biology, Yale University, New Haven, CT 08540, USA

    Frank H. Ruddle

  5. Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 08540, USA

    Günter P. Wagner

  6. The Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA

    Peter F. Stadler

Authors
  1. Sonja J. Prohaska
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  2. Claudia Fried
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  3. Chris T. Amemiya
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  4. Frank H. Ruddle
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  5. Günter P. Wagner
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  6. Peter F. Stadler
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Corresponding author

Correspondence to Peter F. Stadler.

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Prohaska, S.J., Fried, C., Amemiya, C.T. et al. The Shark HoxN Cluster Is Homologous to the Human HoxD Cluster . J Mol Evol 58, 212–217 (2004). https://doi.org/10.1007/s00239-003-2545-z

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