The Thibièrge-Weissenbach syndrome: a rare clinical presentation of generalized soft tissue calcifications associated with scleroderma

Abstract 

Thibièrge-Weissenbach syndrome is a rare entity of generalized soft tissue calcinosis of the hand associated with scleroderma. Patients present with tumorous deformities of the hand and phalanges which are easily misdiagnosed as rheumatoid arthritis. The diagnosis is confirmed by conventional X-rays. Treatment options are limited to local excision of painful or ulcerated nodules. Multiple operations are frequently required due to the high incidence of local recurrence. Two clinical cases and a review of the etiopathogenesis of the Thibièrge-Weissenbach syndrome are presented.