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Prognostic serum biomarker for survival outcome in burn patients

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European Journal of Plastic Surgery Aims and scope Submit manuscript

Abstract

Background

To predict the burn survival outcome, diverse studies were carried out. Some trials reported prognostic scoring systems. However, other studies evaluated the role of different biochemical markers for the same purpose. Inflammation and tissue remodeling may be influenced by serum netrin-1. Our goal was to evaluate the prognostic value of serum netrin-1 level in the survival of burn patients.

Methods

Fifty-two burn patients participated in this prospective trial. Forty-two survived (group 1) and ten patients died (group 2). All patients’ data were gathered including physical examination, laboratory (routine investigations and serum netrin-1 level), and survival outcome. All patients had their serum netrin-1 levels checked once upon admission.

Results

The median level of serum netrin-1 in the non-survivor group was considerably greater than in the survivor group. Serum netrin-1 can be adopted to distinguish between the survivor group and non-survivor one at a cut-off level of > 94 (pg/mL), with 100% sensitivity and 54.76% specificity. Moreover, a significant positive strong correlation was detected between serum netrin-1 level and total burn surface area and prothrombin time.

Conclusions

Serum netrin-1 level could be used as a prognostic serum biomarker for survival outcomes in burn patients.

Level of evidence

Level IV, Risk/Prognostic study

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Funding

The authors did not receive any financial aid, grants, or other forms of assistance for the production of this paper.

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Authors and Affiliations

  1. Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

    Samah M. Elbastawesy & Fatma Gaber

  2. Plastic and Reconstructive Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt

    Mohamed M. Khedr

  3. Emergency Medicine and Traumatology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

    Mohamed A. Shama & Tamer Zidan

  4. Medical Biochemistry department, Faculty of Medicine, Tanta University, Tanta, Egypt

    Asmaa A. Ghalwash

Authors
  1. Samah M. Elbastawesy
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  2. Mohamed M. Khedr
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  4. Tamer Zidan
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  5. Asmaa A. Ghalwash
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  6. Fatma Gaber
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Contributions

Each author made a significant contribution to each of the following:

(1)The conception and design of the study, the collection, analysis, and interpretation of data

(2)Writing the manuscript and analyzing it critically for its critical intellectual material

(3)Acceptance of the submitted version in its entirety

Corresponding author

Correspondence to Mohamed M. Khedr.

Ethics declarations

Ethics approval

The Helsinki Declaration's guiding principles were followed when conducting this study. The clearance came from the university's ethics committee. This article was approved by University Ethics Committee with approval code (36264PR88).

Consent to participate

All patients or their legal guardians gave their written informed consent to participate in the research and to be photographed.

Consent for publication

The authors affirm that all patients or their guardian agreed that the resulted data to be published.

Competing interests

Samah M. Elbastawesy, Mohamed M. Khedr, Mohamed A. Shama, Tamer Zidan, Asmaa A. Ghalwash, and Fatma Gaber declare no competing interests.

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Elbastawesy, S.M., Khedr, M.M., Shama, M.A. et al. Prognostic serum biomarker for survival outcome in burn patients. Eur J Plast Surg 46, 1305–1314 (2023). https://doi.org/10.1007/s00238-023-02087-9

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  • DOI: https://doi.org/10.1007/s00238-023-02087-9

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