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The effect of a silicone sheet on sciatic nerve healing in rats

  • Experimental Study
  • Published:
European Journal of Plastic Surgery Aims and scope Submit manuscript

Abstract

Background

Fibrosis occurs during the healing process after nerve injury. Extraneural fibrosis occurs around the epineural sheath. Intraneural fibrosis occurs in the internal structure of the nerve. Prophylactic treatment with silicone gel sheets is effective in preventing severe scarring in the skin. Nerve action potential (NAP) recording is a well established, simple, and useful tool in the surgical treatment of nerve damage. Our aim in this study was to determine the effect of a silicone sheet on biophysical and histopathologic parameters when used in the treatment of peripheral nerve transection (neurotmesis) and crush injuries.

Methods

The study was conducted with 32 Wistar albino male rats. The rats in the neurotmesis and crush injury groups were divided into study and control groups. Before the injury and after 12 weeks, electrophysiological measurements were obtained. The sciatic nerve biopsy specimens were histopathologically evaluated.

Results

After 12 weeks, there was no statistical difference between pre- and post-injury ΔPP values in the PNR+SS group (p = 0.123). There was no statistically significant difference in post-injury ΔPP values between the CI and CI+SS groups (p = 0.201). The mean total histopathological score was significantly higher in the PNR+SS group than in the PNR group (p = 0.023).

Conclusions

In this rat model, a silicone sheet appears to have positive effects on peripheral nerve healing after primer repair and crush injury.

Level of evidence

Not gradable.

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Funding

Financial assistance was received from Sivas Cumhuriyet University Scientific Research Project.

Author information

Authors and Affiliations

  1. Plastic Reconstructive and Aesthetic Surgery Department, Cumhuriyet University Medical Faculty, 58140, Sivas, Turkey

    Handan Derebaşınlıoğlu

  2. Biophysics Department, Cumhuriyet University Medical Faculty, 58140, Sivas, Turkey

    Ayşe Demirkazık

  3. Plastic Reconstructive and Aesthetic Surgery Department, Republic of Turkey Ministery of Health, Malatya Trainning Resarch Hospital, 44330, Malatya, Turkey

    İnanç Çiçek Doğan

  4. Pathology Department, Cumhuriyet University Medical Faculty, 58140, Sivas, Turkey

    H. Reyhan Eğilmez

  5. Statistics Department, Cumhuriyet University Medical Faculty Hospital, 58140, Sivas, Turkey

    Selim Çam & Neşe Yeldir

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  1. Handan Derebaşınlıoğlu
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Correspondence to Handan Derebaşınlıoğlu.

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Ethical approval

All procedures performed in studies involving animal subjects were in accordance with the ethical standards of the institutional and/or national research committee. This study was also performed in strict accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals. The Cumhuriyet University Ethical Comittee approved this study (decision No: 65202830-050 04 04-243).

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Derebaşınlıoğlu, H., Demirkazık, A., Çiçek Doğan, İ. et al. The effect of a silicone sheet on sciatic nerve healing in rats. Eur J Plast Surg 46, 453–463 (2023). https://doi.org/10.1007/s00238-023-02071-3

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  • DOI: https://doi.org/10.1007/s00238-023-02071-3

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