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Pilot study for permanent resolution of axillary hyperhidrosis: elimination of sweat glands with intradermal microneedle radiofrequency

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Hyperhidrosis is a disorder of the autonomic nervous system that creates severe social and work problems through the production of excess uncontrolled perspiration. This disease affects about 1 to 3% of the world’s population. Essential or primary hyperhidrosis being most frequently seen. Treatment with a variety of surgical and non-surgical systems has been reported. Recently, intradermal microneedle radiofrequency has attracted favorable attention.


Seventy-four armpits in 37 patients (9 males, 28 females, average age 28 years [range 15–68 years]) diagnosed as having axillary hyperhidrosis who were performed intradermal microneedling fractional radiofrequency (MRF) in three deeps 2 mm, 3 mm, and 3.5 mm. The study was performed from July 2014 until July 2016. All patients completed control and follow-up sessions for 6 months.


A permanent decrease in sweating of over 50% was achieved in 30 patients (80%); intermediate results in 2 (7%) and little or no results in 5 patients (13% of patients).


results suggest that MFR is a novel, safe, effective, permanent, and minimally invasive method to treat AHH with tolerable side effects.

Level of Evidence: Level IV, therapeutic study.

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Fabian Perez Rivera declares that he has no conflict of interest.

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For this retrospective study formal consent from a local ethics committee  is not required.

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All patients sign two different consents in which they accept to share their photos and information of the treatment for scientific purposes.

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Perez Rivera, F. Pilot study for permanent resolution of axillary hyperhidrosis: elimination of sweat glands with intradermal microneedle radiofrequency. Eur J Plast Surg 42, 161–168 (2019).

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