European Journal of Plastic Surgery

, Volume 35, Issue 8, pp 613–616 | Cite as

Intralesional cryosurgery for the treatment of basal cell carcinoma in an elderly patient

  • Yaron Har-ShaiEmail author
  • Lior Har-Shai
  • Miriam Lurie
  • Edmond Sabo
Ideas and Innovations


The incidence of basal cell carcinoma (BCC) on the lower extremities of elderly patients, who have co-morbidity, is rising. The surgical technique to treat those skin neoplasms on the legs should take into account difficulties in wound healing, dehiscence, or necrosis of the surgical wound, failed skin grafting, and wound infection due to blood supply and innervation disturbances and reduced quality of the skin. Spray/contact cryosurgery is one of the well-established, older therapies for BCC and is widely used with hardly any contraindications and with a high cure rate. This case report is the first in the medical literature to present a successful removal of two BCCs on the leg of an elderly patient by employing a novel and new intralesional cryosurgery technology.


Intralesional cryosurgery BCC Lower extremity Elderly patient 


Conflict of interest

The author Y.H.S has a financial interest in the intralesional cryosurgery technology.


  1. 1.
    Roewert-Huber J, Lange-Asschenfeldt B, Stockfleth E, Kerl H (2007) Epidemiology and aetiology of basal cell carcinoma. Br J Dermatol 2:47–51CrossRefGoogle Scholar
  2. 2.
    Peikert JM (2011) Prospective trial of curettage and cryosurgery in the management of non-facial, superficial, and minimally invasive basal and squamous cell carcinoma. Int J Dermatol 50:1135–1138PubMedCrossRefGoogle Scholar
  3. 3.
    Roenigk RK, Ratz JK, Bailin PL, Wheeland RG (1984) Trends in the presentation of BCC. J Dermatol Surg Oncol 12:860–865Google Scholar
  4. 4.
    Carlson KC, Connolly SM, Winkelmann RK (1994) Basal cell carcinoma on the lower extremity. J Dermatol Surg Oncol 20:258–259PubMedGoogle Scholar
  5. 5.
    Giles GG, Marks R, Foley P (1988) Incidence of non-melanocytic skin cancer treated in Australia. Br Med J 296:13–17CrossRefGoogle Scholar
  6. 6.
    Scrivener Y, Grosshans E, Cribier B (2002) Variations of BCC according to gender, age, location and histopathological subtype. Br J Dermatol 147:41–47PubMedCrossRefGoogle Scholar
  7. 7.
    Betti R, Radaelli G, Mussino F, Menni S, Crosti C (2009) Anatomic location and histopathologic subtype of BCC in adults younger than 40 or 90 and older: any difference? Dermatol Surg 35:201–206PubMedCrossRefGoogle Scholar
  8. 8.
    Wang Y, Li J, Xu YW, Buaijiaer HS, Yang JG, Yuan H, Hu DY (2009) Prevalence of peripheral arterial disease and correlative risk factors among natural population in China. Zhonghua Xin Xue Guan Bing Za Zhi 37:1127–1131PubMedGoogle Scholar
  9. 9.
    Mani R, Yarde S, Edmonds M (2011) Prevalence of deep venous incompetence and microvascular abnormalities in patients with diabetes mellitus. Int J Low Extrem Wounds 10:75–79PubMedCrossRefGoogle Scholar
  10. 10.
    Har-Shai Y, Amar M, Sabo E (2003) Intralesional cryotherapy for enhancing the involution of hypertrophic scars and keloids. Plast Reconstr Surg 111:1841–1852PubMedCrossRefGoogle Scholar
  11. 11.
    Har-shai Y, Dujovny E, Rohde E, Zouboulis CC (2007) Effect of skin surface temperature on skin pigmentation during contact and intralesional cryosurgery of keloids. J Eur Acad Dermatol Venereol 21:191–198PubMedCrossRefGoogle Scholar
  12. 12.
    Har-Shai Y, Sabo E, Rohde E, Hyams M, Assaf C, Zouboulis CC (2006) Intralesional cryosurgery enhances the involution of recalcitrant auricular keloids: a new clinical approach supported by experimental studies. Wound Repair Regen 14:18–27PubMedCrossRefGoogle Scholar
  13. 13.
    Har-Shai Y, Brown W, Labbé D, Dompmartin A, Goldine I, Gil T, Mettanes I, Pallua N (2008) Intralesional cryosurgery for the treatment of hypertrophic scars and keloids following aesthetic surgery: the results of a prospective observational study. Int J Low Extrem Wounds 7:169–175PubMedCrossRefGoogle Scholar
  14. 14.
    Har-Shai Y, Brown W, Pallua N, Zouboulis CC (2010) Intralesionl cryosurgery for the treatment of hypertrophic scars and keloids (letter). Plast Reconst Surg 126:1798–1800PubMedGoogle Scholar
  15. 15.
    Har-Shai Y, Mettanes I, Genin O, Spector I, Pines M (2010) Keloid histopathology after intralesional cryoneedle treatment. J Eur Acad Dermatol Venereol 25:1027–36APubMedCrossRefGoogle Scholar
  16. 16.
    Mirmovich O, Gil T, Lavi I, Goldine I, Mettanes I, Har-Shai Y (2012) Pain evaluation and control during and following the treatment of hypertrophic scars and keloids employing contact and intralesional cryosurgery-a preliminary study. J Eur Acad Dermatol Venereol (in press)Google Scholar
  17. 17.
    Kuflik EG (2004) Cryosurgery for skin cancer: 30-year experience and cure rates. Dermatol Surg 30:297–300PubMedCrossRefGoogle Scholar
  18. 18.
    Soanes WA, Albin RJ, Gonder MJ (1970) Remission of metastatic lesions following cryosurgery in prostatic cancer: immunologic considerations. J Urol 140:154–159Google Scholar
  19. 19.
    Joosten JJ, Muijen GN, Wobbes MJ, Ruers TJ (2001) In vivo destruction of tumor tissue by cryoablation can induce inhibitions of secondary tumor growth: an experimental study. Cryobiology 42:49–58PubMedCrossRefGoogle Scholar
  20. 20.
    Messeguer F, Serra-Guillen C, Echeverria B, Requena C, Sanmartin O, Llombart C, Guillen C, Nagore E (2012) A pilot study of clinical efficacy of imiquimod and cryotherapy for the treatment of BCC with incomplete response to imiquimod. J Eur Acad Dermatol Venereol (in press)Google Scholar
  21. 21.
    Andrews MD (2004) Cryosurgery for common skin conditions. Am Fam Physician 69:2365–2372PubMedGoogle Scholar
  22. 22.
    Weshahy AH (1993) Intralesional cryosurgery, a new technique using cryoneedles. J Dermatol Surg Oncol 19:123–126PubMedGoogle Scholar
  23. 23.
    Baust JC, Gage AA (2005) The molecular basis of cryosurgery. Br J Urol Int 95:1187–1191CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Yaron Har-Shai
    • 1
    Email author
  • Lior Har-Shai
    • 4
  • Miriam Lurie
    • 2
  • Edmond Sabo
    • 3
  1. 1.The Unit of Plastic SurgeryCarmel Medical CenterHaifaIsrael
  2. 2.Department of PathologyCarmel Medical CenterHaifaIsrael
  3. 3.Department of PathologyRambam Medical CenterHaifaIsrael
  4. 4.The Bruce Rapapport Faculty of MedicineTechnion-Israel Institute of TechnologyHaifaIsrael

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